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Submit ReviewCD 3254
Description: Potent and selective RXRα agonist
Chemical Name: 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoic acid
Purity: ≥97% (HPLC)
Biological Activity for CD 3254
CD 3254 is a selective RXRα agonist; exhibits no activity at RARα, RARβ or RARγ receptors. CD 3254 can promote chemical reprogramming of mouse fibroblasts. In a fast chemical reprogramming protocol, it promotes reprogramming of foetal mouse dorsal fibroblasts (MDFs) and adult mouse lung fibroblasts (MLFs) to iPS cells within 12 days.
Compound Libraries for CD 3254
CD 3254 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CD 3254
| M. Wt | 364.48 |
| Formula | C24H28O3 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 196961-43-0 |
| PubChem ID | 44566110 |
| InChI Key | DYLLZSVPAUUSSB-VQHVLOKHSA-N |
| Smiles | CC1(C)C2=C(C=C(C3=C(O)C=CC(/C=C/C(O)=O)=C3)C(C)=C2)C(C)(C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CD 3254
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.45 | 100 | |
| ethanol | 36.45 | 100 |
Preparing Stock Solutions for CD 3254
The following data is based on the product molecular weight 364.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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Product Datasheets for CD 3254
References for CD 3254
References are publications that support the biological activity of the product.
Pogenberg et al (2005) Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. J.Biol.Chem. 280 1625 PMID: 15528208
le Maire et al (2009) Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO.Rep. 10 367 PMID: 19270714
Nahoum et al (2007) Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci. 104 17323 PMID: 17947383
Jin et al (2023) Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception. Proc.Natl.Acad.Sci. 23 120 PMID: 37192170
Chen et al (2023) A fast chemical reprogramming system promotes cell identity transition through a diapause-like state. Nat.Cell Biol. 25 1146 PMID: 37550515
If you know of a relevant reference for CD 3254, please let us know.
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Keywords: CD 3254, CD 3254 supplier, Potent, selective, RXR, agonists, CD3254, aRXR, alphaRXR, αRXR, retinoid, X, receptor, fast, chemical, reprogramming, iPS, Retinoid, Receptor, Stem, Cell, Reprogramming, 3302, Tocris Bioscience
1 Citation for CD 3254
Citations are publications that use Tocris products. Selected citations for CD 3254 include:
Wang et al (2017) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol 9 338 PMID: 28992291
Do you know of a great paper that uses CD 3254 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.