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Submit ReviewAlfuzosin hydrochloride
Discontinued Product
3305 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
Description: Uroselective α1 antagonist
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Alfuzosin hydrochloride
Alfuzosin hydrochloride is a functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.
Technical Data for Alfuzosin hydrochloride
| M. Wt | 425.91 |
| Formula | C19H27N5O4.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 81403-68-1 |
| PubChem ID | 71764 |
| InChI Key | YTNKWDJILNVLGX-UHFFFAOYSA-N |
| Smiles | NC2=NC(N(C)CCCNC(C3CCCO3)=O)=NC1=CC(OC)=C(OC)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Alfuzosin hydrochloride
References for Alfuzosin hydrochloride
References are publications that support the biological activity of the product.
Palea and Barras (2003) Comparison of the relaxant effects of alfuzosin, phentol. and silde. on rabbit isolated corpus cavernosum. BJU Int. 91 873 PMID: 12780851
Lee (2003) Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia. Am.J.Health Syst.Pharm. 60 1426 PMID: 12892027
Yamaguchi et al (2005) Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes. J.Smooth Muscle Res. 41 247 PMID: 16428864
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Keywords: Alfuzosin hydrochloride, Alfuzosin hydrochloride supplier, Uroselective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, antagonists, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 3305, Tocris Bioscience
Citations for Alfuzosin hydrochloride
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Currently there are no citations for Alfuzosin hydrochloride.
Reviews for Alfuzosin hydrochloride
Average Rating: 4 (Based on 1 Review.)
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Used to investigate cell metabolism.
By
Anonymous on 02/27/2023
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons
The drug was incubated at 10 μM to investigate a potential effect on cell metabolism.
Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.