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Submit ReviewFluvastatin sodium
Description: Potent HMG-CoA reductase inhibitor
Chemical Name: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt
Purity: ≥98% (HPLC)
Biological Activity for Fluvastatin sodium
Fluvastatin sodium is an orally active, potent and competitive HMG-CoA reductase inhibitor (IC50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo.
Compound Libraries for Fluvastatin sodium
Fluvastatin sodium is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Fluvastatin sodium
| M. Wt | 433.45 |
| Formula | C24H25FNNaO4 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 93957-55-2 |
| PubChem ID | 76969265 |
| InChI Key | BNZHURJBOKXWJX-ZKBIPVLYSA-L |
| Smiles | [Na+].[Na+].CC(C)N1C(\C=C\[C@H](O)C[C@H](O)CC([O-])=O)=C(C2=CC=C(F)C=C2)C2=C1C=CC=C2.CC(C)N1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C2=CC=C(F)C=C2)C2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fluvastatin sodium
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.84 | 25 | |
| DMSO | 43.34 | 100 |
Preparing Stock Solutions for Fluvastatin sodium
The following data is based on the product molecular weight 433.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.54 mL | 23.07 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for Fluvastatin sodium
References for Fluvastatin sodium
References are publications that support the biological activity of the product.
Dansette et al (2000) HMG-CoA reductase activity in human liver microsomes: comparative inhibition by STAT. Exp.Toxicol.Pathol. 52 145 PMID: 10965989
Yamamoto et al (2001) Antioxidative effects of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. J.Pharm.Pharmacol. 53 227 PMID: 11273020
Turner et al (2007) Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458 PMID: 18049315
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Keywords: Fluvastatin sodium, Fluvastatin sodium supplier, HMG-CoA, reductases, inhibitors, inhibits, statins, Reductase, 3309, Tocris Bioscience
5 Citations for Fluvastatin sodium
Citations are publications that use Tocris products. Selected citations for Fluvastatin sodium include:
Bergman et al (2011) Studies on the antibacterial effects of STAT--in vitro and in vivo. PLoS One 6 e24394 PMID: 21912631
Li and Fountain (2012) Fluvastatin suppresses native and recombinant human P2X4 receptor function. Purinergic Signal 8 311 PMID: 22222818
Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401
Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942
Vainio et al (2011) Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT. Am J Physiol Renal Physiol 2 1176 PMID: 22202492
Do you know of a great paper that uses Fluvastatin sodium from Tocris? Please let us know.
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