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Submit ReviewEndomorphin-1
Discontinued Product
1055 has been discontinued.
Description: Potent and selective μ agonist
Purity: ≥95% (HPLC)
Biological Activity for Endomorphin-1
Endomorphin-1 is a endogenous peptide with an exceptionally high affinity (Ki = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).
Technical Data for Endomorphin-1
| M. Wt | 610.67 |
| Formula | C34H38N6O5 |
| Sequence |
YPWF (Modification: Phe-4 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 189388-22-5 |
| PubChem ID | 5311080 |
| InChI Key | ZEXLJFNSKAHNFH-SYKYGTKKSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Endomorphin-1
References for Endomorphin-1
References are publications that support the biological activity of the product.
Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007 PMID: 9694962
Harrison et al (1998) Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 19 749 PMID: 9622031
Kakizawa et al (1998) Parallel stimulations of in vitro and in situ [35S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 19 755 PMID: 9622032
Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499 PMID: 9087409
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Keywords: Endomorphin-1, Endomorphin-1 supplier, Potent, selective, μ-opioid, mu-opioid, agonists, MOP, Receptors, OP3, Mu, Opioid, 1055, Tocris Bioscience
3 Citations for Endomorphin-1
Citations are publications that use Tocris products. Selected citations for Endomorphin-1 include:
Hauser et al (2018) Pharmacogenomics of GPCR Drug Targets. Cell 172 41 PMID: 29249361
Garzón et al (2004) RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology 29 1091 PMID: 14997173
Dortch-Carnes and Russell (2007) Morphine-stimulated nitric oxide release in rabbit aqueous humor. Am J Physiol Endocrinol Metab 84 185 PMID: 17094965
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