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Submit ReviewCART (62-76) (rat, human)
Description: Neuromodulating neuropeptide fragment; inhibits food intake in vivo
Alternative Names: Cocaine and amphetamine-regulated transcript (62-76) (rat,human)
Biological Activity for CART (62-76) (rat, human)
CART (62-76) (rat, human) is a cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain.
Technical Data for CART (62-76) (rat, human)
| M. Wt | 1570.77 |
| Formula | C64H99N17O23S3 |
| Sequence | YGQVPMCDAGEQCAV |
| Storage | Store at -20°C |
| CAS Number | 210978-19-1 |
| PubChem ID | 90488836 |
| InChI Key | PSFNEVMDUKVDPJ-XJHNVALUSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CART (62-76) (rat, human)
References for CART (62-76) (rat, human)
References are publications that support the biological activity of the product.
Volkoff and Peter (2000) Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding. Brain Res. 887 125 PMID: 11134597
Vaarmann and Kask (2001) Cocaine and amphetamine-regulated transcript peptide (CART62-76)-induced changes in regional monoamine levels in rat brain. Neuropeptides 35 292 PMID: 12030814
Colombo et al (2003) Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on release of Ins from isolated rat islets. Pancreas 27 161 PMID: 12883265
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Keywords: CART (62-76) (rat, human), CART (62-76) (rat, human) supplier, Neuromodulating, neuropeptide, fragment, inhibits, inhibitors, food, intake, vivo, Peptide, Receptor, Receptors, Cocaine, amphetamine-regulated, transcript, CART, peptide, amphetamine, neuropeptides, cart62-76, and, (62-76), (rat,, human), Other, 3339, Tocris Bioscience
Citations for CART (62-76) (rat, human)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.