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Submit ReviewClomipramine hydrochloride
Description: 5-HT reuptake inhibitor
Chemical Name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Clomipramine hydrochloride
Clomipramine hydrochloride is a potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a Ki of 0.05 nmol/l.
Technical Data for Clomipramine hydrochloride
| M. Wt | 351.32 |
| Formula | C19H23ClN2.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 17321-77-6 |
| PubChem ID | 68539 |
| InChI Key | WIMWMKZEIBHDTH-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)CCCN1C2=CC(Cl)=CC=C2CCC2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Clomipramine hydrochloride
References for Clomipramine hydrochloride
References are publications that support the biological activity of the product.
McTavish and Benfield (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39 136 PMID: 2178909
Ortiz and Artiga (1992) Effects of monoamine uptake inhibitors on extracellular and platelet 5-hydroxytryptamine in rat blood: different effects of clomipramine and fluox. Br.J.Pharmacol. 105 941 PMID: 1387022
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006
Merck Index 12 2447
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Keywords: Clomipramine hydrochloride, Clomipramine hydrochloride supplier, 5HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 5-HT, 0457, Tocris Bioscience
3 Citations for Clomipramine hydrochloride
Citations are publications that use Tocris products. Selected citations for Clomipramine hydrochloride include:
Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Eur J Neurosci 352 53 PMID: 25332454
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
Duncan et al (2010) The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors. J Biomed Sci 31 1646 PMID: 20525077
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.