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MIRA-1

Cat. No. 3362 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Restores mutant p53 activity; proapoptotic
Chemical Name: 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Datasheet
Citations (1)
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MIRA-1

MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM).

Technical Data for MIRA-1

M. Wt 183.16
Formula C8H9NO4
Storage Store at +4°C
CAS Number 72835-26-8
PubChem ID 227681
InChI Key YXEWPGYLMHXLPS-UHFFFAOYSA-N
Smiles O=C(N1COC(CC)=O)C=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MIRA-1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.32 100
ethanol 18.32 100

Preparing Stock Solutions for MIRA-1

The following data is based on the product molecular weight 183.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.46 mL 27.3 mL 54.6 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
10 mM 0.55 mL 2.73 mL 5.46 mL
50 mM 0.11 mL 0.55 mL 1.09 mL

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References for MIRA-1

References are publications that support the biological activity of the product.

Bykov et al (2005) Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 280 30384 PMID: 15998635

Wiman (2006) Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 13 921 PMID: 16557267

Kumar et al (2007) p53 in breast cancer: mutation and countermeasures. Front.Biosci. 12 4168 PMID: 17485365

If you know of a relevant reference for MIRA-1, please let us know.

View Related Products by Target

Keywords: MIRA-1, MIRA-1 supplier, Restores, mutant, p53, activity, proapoptotic, Transcription, Factors, 3362, Tocris Bioscience

1 Citation for MIRA-1

Citations are publications that use Tocris products. Selected citations for MIRA-1 include:

Saha et al (2014) Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. Br J Cancer 110 2224 PMID: 24691427

Do you know of a great paper that uses MIRA-1 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for MIRA-1

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.