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Submit ReviewGW 791343 hydrochloride
Description: Allosteric modulator of P2X7 receptors
Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for GW 791343 hydrochloride
GW 791343 hydrochloride is a P2X7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X7.
Technical Data for GW 791343 hydrochloride
| M. Wt | 483.81 |
| Formula | C20H24F2N4O.3HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 309712-55-8 |
| PubChem ID | 9848159 |
| InChI Key | WSBRAHWNJBXXJM-UHFFFAOYSA-N |
| Smiles | CC(C=C2)=C(NC(CNC3=CC=C(F)C(F)=C3)=O)C=C2CN1CCNCC1.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GW 791343 hydrochloride
References for GW 791343 hydrochloride
References are publications that support the biological activity of the product.
Michel et al (2008) Negative and positive allosteric modulators of the P2X7 receptor. Br.J.Pharmacol. 153 737 PMID: 18071294
Michel et al (2008) Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects. Br.J.Pharmacol. 155 738 PMID: 18660826
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Citations for GW 791343 hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.