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Description: Potent and selective non-NMDA iGluR antagonist
Alternative Names: Cyanquixaline
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione
Purity: ≥99% (HPLC)
Biological Activity for CNQX
CNQX is an AMPA and kainate receptor antagonist (IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively). CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX can be used to isolate GABAA receptor-mediated spontaneous inhibitory postsynaptic currents and antagonizes non-NMDA receptor-mediated responses in cultured cerebellar granule cells. CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.
CNQX Disodium Salt (Cat. No. 1045) also available.
Compound Libraries for CNQX
CNQX is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CNQX
| M. Wt | 232.16 |
| Formula | C9H4N4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 115066-14-3 |
| PubChem ID | 3721046 |
| InChI Key | RPXVIAFEQBNEAX-UHFFFAOYSA-N |
| Smiles | [O-][N+](=O)C1=C(C=C2NC(=O)C(=O)NC2=C1)C#N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CNQX
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.22 | 100 |
Preparing Stock Solutions for CNQX
The following data is based on the product molecular weight 232.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.31 mL | 21.54 mL | 43.07 mL |
| 5 mM | 0.86 mL | 4.31 mL | 8.61 mL |
| 10 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets for CNQX
References for CNQX
References are publications that support the biological activity of the product.
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909
King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375 PMID: 1358390
Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850 PMID: 1976402
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495
If you know of a relevant reference for CNQX, please let us know.
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Keywords: CNQX, CNQX supplier, Potent, AMPA/kainate, antagonists, antagonism, NMDA, glycine, site, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, N-Methyl-D-Aspartate, neuroprotective, Cyanquixaline, 0190, Tocris Bioscience
214 Citations for CNQX
Citations are publications that use Tocris products. Selected citations for CNQX include:
Zhou et al (2018) The Mouse Pulvinar Nucleus Links the Lateral Extrastriate Cortex, Striatum, and Amygdala. J Neurosci 38 347 PMID: 29175956
Chuhma et al (2018) DA neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons. Elife 7 PMID: 30295607
Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab 13 584 PMID: 21531340
Mahajan et al (2011) Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 189 305 PMID: 21620933
Zhao et al (2011) Homeostatic synaptic plasticity through changes in presynaptic calcium influx. Hear Res 31 7492 PMID: 21593333
Couchman et al (2011) Lateral superior olive function in congenital deafness. J Neurosci 277 163 PMID: 21276842
Chung et al (2011) Expression and functional properties of TRPM2 channels in DArgic neurons of the substantia nigra of the rat. Front Neural Circuits 106 2865 PMID: 21900507
Lazarevic et al (2011) Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. J Neurosci 31 10189 PMID: 21752995
Meehan et al (2011) A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of LeveT. J Biol Chem 106 1227 PMID: 21653714
Porcher et al (2011) Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. Front Neural Circuits 286 21667 PMID: 21474450
Kaminski et al (2011) 11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice. Proc Natl Acad Sci U S A 60 1098 PMID: 20883706
Oh et al (2010) Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor. J Neurosci 285 30825 PMID: 20643652
Yeh et al (2010) SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathog 6 e1001207 PMID: 21124874
Noh et al (2010) Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map. Neuropharmacology 13 232 PMID: 20081852
Gonzalez-Islas et al (2010) GABAergic synaptic scaling in embryonic motoneurons is mediated by a shift in the chloride reversal potential. J Neurosci 30 13016 PMID: 20881119
Acuna-Goycolea et al (2010) Cannabinoids excite circadian clock neurons. J Neurosci 30 10061 PMID: 20668190
Kelley et al (2008) Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization. J Neurochem 107 668 PMID: 18699862
Brager and Johnston (2007) Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci 27 13926 PMID: 18094230
Marsden et al (2007) NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors. J Neurosci 27 14326 PMID: 18160640
Zhu et al (2007) Tyramine excites rat subthalamic neurons in vitro by a DA-dependent mechanism. Neuropharmacology 52 1169 PMID: 17291545
Röther et al (2014) Dynamic properties of the alkaline vesicle population at hippocampal synapses. PLoS One 9 e102723 PMID: 25079223
Easton et al (2014) Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J Neurosci 34 3854 PMID: 24623764
Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284 PMID: 24518663
Tamura et al (2014) Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum. PLoS One 9 e85351 PMID: 24454845
Wang et al (2014) Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice. PLoS One 9 e92279 PMID: 24637500
Rossi et al (2014) Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener 9 56 PMID: 25495224
Wang et al (2014) Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria. Cereb Cortex 24 1088 PMID: 23246779
Qiu et al (2014) GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci 34 13505 PMID: 25274827
Liu et al (2017) IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning. Neuron 95 106 PMID: 28683263
Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816
Pose-Utrilla et al (2017) Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1. Nat Commun 8 2275 PMID: 29273751
Sun et al (2017) Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall. Neuron 95 656 PMID: 28772124
Leal et al (2017) The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons. Eneuro 4 PMID: 29255796
Zhu et al (2011) Suppression of PKR promotes network excitability and enhanced cognition by IF.-γ-mediated disinhibition. Cell 147 1384 PMID: 22153080
Welzel et al (2011) Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses. Biophys J 100 593 PMID: 21281573
Zschenderlein et al (2011) Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1. PLoS One 6 e16116 PMID: 21249195
Parker et al (2011) Attenuating GABA(A) receptor signaling in DA neurons selectively enhances reward learning and alters risk preference in mice. J Neurosci 31 17103 PMID: 22114279
Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051 PMID: 21123660
Bright et al (2011) Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover. J Neurosci 31 753 PMID: 21228184
Kopach et al (2011) Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn. Pain 152 912 PMID: 21282008
Mark et al (2011) Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J Neurosci 31 4311 PMID: 21411672
Case et al (2011) Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat. PLoS One 6 e20756 PMID: 21694776
Khalilov et al (2011) Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. Front Cell Neurosci 5 23 PMID: 22065950
Herman et al (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression Nature 538 253 PMID: 27698417
Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240 PMID: 27687783
Hong et al (2008) Glutamatergic transmission is sustained at a later period of development of medial nucleus of the trapezoid body-lateral superior olive synapses in circling mice. J Neurosci 28 13003 PMID: 19036993
Gitler et al (2008) Synapsin IIa controls the reserve pool of glutamatergic synaptic vesicles. J Neurosci 28 10835 PMID: 18945891
Frischknecht et al (2008) Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci 28 1568 PMID: 18272678
Costa et al (2008) Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition. J Neurosci 28 8040 PMID: 18685029
Darbin and Wichmann (2008) Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys. Nat Neurosci 99 1294 PMID: 18216224
Schönberger et al (2014) Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes. J Neurosci 8 103 PMID: 25202239
Pan et al (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. Eur J Neurosci 124 4629 PMID: 25202982
Oostland et al (2014) Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice. J Neurophysiol 13 491 PMID: 24788088
Purohit et al (2014) The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons. J Biol Chem 9 e103976 PMID: 25133820
Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports 3 282 PMID: 25254342
Woo et al (2014) Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response. Exp Neurobiol 23 163 PMID: 24963281
Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep 7 7363 PMID: 28779174
Chen et al (2017) Amygdalar endothelin-1 regulates pyramidal neuron excitability and affects anxiety. Sci Rep 7 2316 PMID: 28539637
Yeo et al (2009) Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride. J Neurosci 29 14652 PMID: 19923298
Tsuriel et al (2009) Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule bassoon. PLoS One 29 351 PMID: 19144835
Prat et al (2009) Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. J Neurosci 5 e1000425 PMID: 19424436
Lin et al (2008) Integrin regulation of cytoplasmic calcium in excitatory neurons depends upon glutamate receptors and release from intracellular stores. Cerebellum 37 770 PMID: 18289871
Petzold et al (2008) Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron 58 897 PMID: 18579080
Pozzi et al (2008) Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels. Proc Natl Acad Sci U S A 105 323 PMID: 18162553
Guire et al (2008) Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I. J Neurosci 28 6000 PMID: 18524905
Puranam et al (2015) Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. J Neurosci 35 8866 PMID: 26063919
Baquero et al (2015) Developmental changes in synaptic distribution in arcuate nucleus neurons. Glia 35 8558 PMID: 26041922
Garthwaite et al (2015) Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Front Cell Neurosci 63 383 PMID: 25327839
Gao et al (2015) Dendritic morphology, synaptic transmission, and activity of mature granule cells born following PilC-induced status epilepticus in the rat. Front Cell Neurosci 9 384 PMID: 26500490
Lamanna et al (2015) A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP. Cell Rep 9 44 PMID: 25741239
Jacoby et al (2015) An Amacrine Cell Circuit for Signaling Steady Illumination in the Retina. Br J Pharmacol 13 2663 PMID: 26711334
Connor et al (2015) β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons. Elife 172 492 PMID: 24597632
Bryant et al (2015) Cholinergic control of γ power in the midbrain spatial attention network. J Neurosci 35 761 PMID: 25589769
Campbell et al (2015) GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Nat Commun 63 23 PMID: 25066727
Ciani et al (2015) Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Front Neurol 6 8302 PMID: 26400647
Haselmann et al (2015) Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo. Cell Death Dis 6 136 PMID: 26124746
Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. PLoS One 6 e1791 PMID: 26086964
Taylor-Burds et al (2015) Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. J Clin Invest 10 e0131076 PMID: 26110920
Duc et al (2015) Bursting reverberation as a multiscale neuronal network process driven by synaptic depression-facilitation. J Neurosci 10 e0124694 PMID: 26017681
Assous (2017) Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun 8 15860 PMID: 28604688
Gu et al (2015) miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun 6 6789 PMID: 25858512
Gao et al (2015) Role of brain-derived neurotrophic factor in the excitatory-inhibitory imbalance during the critical period of postnatal respiratory development in the rat. Physiol Rep 3 PMID: 26603459
Zou et al (2015) Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development. J Neurosci 35 11384 PMID: 26269645
Zhang et al (2015) Presynaptic mechanisms of lead neurotoxicity: effects on vesicular release, vesicle clustering and mitochondria number. PLoS One 10 e0127461 PMID: 26011056
Neuner et al (2015) TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res 281 69 PMID: 25513972
Sexton and Gelder (2015) G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells. PLoS One 10 e0128690 PMID: 26069965
Medrihan et al (2015) Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse. Cereb Cortex 25 3356 PMID: 24962993
Woo et al (2019) Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient. Exp Neurobiol 28 30 PMID: 30853822
Yu et al (2019) KA metabolite (2R,6R)-hydroxynorKA enhances aggression via periaqueductal gray glutamatergic transmission. Neuropharmacology 157 PMID: 31207251
Octeau et al (2019) Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation. Cell Rep 27 2249 PMID: 31116972
Fagiolini et al (2003) Separable features of visual cortical plasticity revealed by N-MthD.-aspartate receptor 2A signaling. J Neurophysiol 100 2854 PMID: 12591944
Kitano et al (2003) Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel. J Biol Chem 278 25101 PMID: 12704197
Jo and Role (2002) Cholinergic modulation of purinergic and GABAergic co-transmission at in vitro hypothalamic synapses. J Neurophysiol 88 2501 PMID: 12424289
Chen et al (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa J Virol 76 9407 PMID: 12186923
Thomet et al (2000) A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188. Br J Pharmacol 131 843 PMID: 11030736
Krucker et al (2000) Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proc Natl Acad Sci U S A 97 6856 PMID: 10823894
Dunaevsky et al (1999) Developmental regulation of spine motility in the mammalian central nervous system. Proc Natl Acad Sci U S A 96 13438 PMID: 10557339
Lledo et al (1996) Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus. Proc Natl Acad Sci U S A 93 2403 PMID: 8637886
Raman and Trussell (1995) Concentration-jump analysis of voltage-dependent conductances activated by glutamate and kainate in neurons of the avian cochlear nucleus. PLoS Pathog 69 1868 PMID: 8580330
Yokoi et al (1995) Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb. Proc Natl Acad Sci U S A 92 3371 PMID: 7724568
Markram and Sakmann (1994) Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels. Proc Natl Acad Sci U S A 91 5207 PMID: 8197208
Sinnayah et al Feeding induced by cannabinoids is mediated independently of the melanocortin system. PLoS One 3 e2202 PMID: 18493584
Romanos et al (2019) Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation. Commun Biol 2 127 PMID: 30963115
Yu et al (2019) Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice. Mol Brain 12 29 PMID: 30935412
Copeland et al (2017) Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation. Neuropharmacology 121 100 PMID: 28416443
Sun et al (2011) Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse. PLoS One 6 e23765 PMID: 21887314
Calfa et al (2011) Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging. J Neurophysiol 105 1768 PMID: 21307327
Viemari et al (2011) Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci 33 2228 PMID: 21615559
Wu et al (2011) Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons. J Neurosci 31 2638 PMID: 21325532
Li et al (2011) Concurrent imaging of synaptic vesicle recycling and calcium dynamics. Front Mol Neurosci 4 34 PMID: 22065946
Corcoran et al (2011) NMDA receptors in retrosplenial cortex are necessary for retrieval of recent and remote context fear memory. J Neurosci 31 11655 PMID: 21832195
Clark et al (2011) Endogenous brain-derived neurotrophic factor in the nucleus tractus solitarius tonically regulates synaptic and autonomic function. J Neurosci 31 12318 PMID: 21865474
Kitagawa et al (2009) Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol 5 280 PMID: 19536203
Chao et al (2009) Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex. Cell Mol Life Sci 66 1105 PMID: 19189047
Chudomel et al (2009) Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat. Neuroscience 163 155 PMID: 19531372
Chuhma et al (2009) DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068 PMID: 19729052
Wu et al (2004) Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain DA neurons. J Pharmacol Exp Ther 311 80 PMID: 15178698
Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923
Moran et al (2004) Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation. J Neurophysiol 92 3266 PMID: 15295007
Fukui and Ohmori (2004) Tonotopic gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis. PLoS One 24 7514 PMID: 15329398
Laricchiuta et al (2012) Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission. PLoS One 7 e33260 PMID: 22413007
Tozzi et al (2012) Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. Proc Natl Acad Sci U S A 109 18985 PMID: 23112192
Hulme et al (2012) Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus. J Neurosci 32 6785 PMID: 22593048
Xiao et al (2012) The role of inhibition in oscillatory wave dynamics in the cortex. Eur J Neurosci 36 2201 PMID: 22805065
Rossi et al (2012) Interleukin-1β causes anxiety by interacting with the endocannabinoid system. J Neurosci 32 13896 PMID: 23035099
Gaier et al (2010) Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci 30 13656 PMID: 20943906
Broadbent et al (2010) Sustained dorsal hippocampal activity is not obligatory for either the maintenance or retrieval of long-term spatial memory. Hippocampus 20 1366 PMID: 19921702
Mancilla (2009) Two distinct types of inhibition mediated by cartwheel cells in the dorsal cochlear nucleus. J Neurophysiol 102 1287 PMID: 19474167
Lörincz et al (2009) ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks. PLoS One 4 e4447 PMID: 19212445
Park et al (2009) Role of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in complete Freund's adjuvant-induced inflammatory pain. Mol Pain 4 67 PMID: 19116032
Kettunen et al (2005) Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network. Neuron 45 95 PMID: 15629705
Choi et al (2005) Multiple receptors coupled to phospholipase C gate long-term depression in visual cortex. J Neurosci 25 11433 PMID: 16339037
Pieri et al (2005) AMPA receptors are modulated by tachykinins in rat cerebellum neurons. J Neurophysiol 94 2484 PMID: 16160091
Li et al (2005) Cortical injury affects short-term plasticity of evoked excitatory synaptic currents. J Neurophysiol 93 146 PMID: 15342719
Kinney (2005) GAT-3 transporters regulate inhibition in the neocortex. Mol Cell Neurosci 94 4533 PMID: 16135550
Ying and Goldstein (2005) PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. Mol Pain 1 2 PMID: 15813991
Micheva and Smith (2005) Strong effects of subphysiological temperature on the function and plasticity of mammalian presynaptic terminals. J Neurophysiol 25 7481 PMID: 16107635
Karst and Joels (2005) Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells. J Neurosci 94 3479 PMID: 16033944
Sylantyev et al (2005) A parametric assessment of GABA antagonist effects on paired-pulse facilitation in the rat anterior cingulate cortex. Neurosci Res 52 362 PMID: 15936838
Hamilton et al (2005) Properties of external plexiform layer interneurons in mouse olfactory bulb slices. Neuroscience 133 819 PMID: 15896912
Sinagra et al (2005) Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. PLoS One 25 6127 PMID: 15987942
Liu et al (2004) Astrocyte-mediated activation of neuronal kainate receptors. Proc Natl Acad Sci U S A 101 3172 PMID: 14766987
Accardi et al (2014) Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun 5 3168 PMID: 24430741
Li et al (2014) Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats. J Neurophysiol 111 145 PMID: 24068759
Fan et al (2018) All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods 15 823 PMID: 30275587
Ben-Mabrouk and Tryba (2010) Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Front Cell Neurosci 31 1219 PMID: 20345918
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID: 20519319
Han et al (2010) Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction. Am J Physiol Regul Integr Comp Physiol 299 R129 PMID: 20164200
Bernard and Zhang (2015) MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism. PLoS One 10 e0124816 PMID: 25932647
Sengupta and Thirumalai (2015) AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae. J Neurophysiol 4 PMID: 26416140
Bäckström and Hyytiä (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 778 PMID: 16123768
Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527
Amadoro et al (2006) NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A 103 2892 PMID: 16477009
Roberto et al (2006) Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala. Neuropsychopharmacology 31 988 PMID: 16052244
Lieske and Ramirez (2006) Pattern-specific synaptic mechanisms in a multifunctional network. I. Effects of alterations in synapse strength. J Neurophysiol 95 1323 PMID: 16492944
Kuriu et al (2006) Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms. J Neurosci 26 7693 PMID: 16855097
Giordano et al (2006) Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol Pharmacol 70 2116 PMID: 17000861
He and Bausch (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis. Neuropharmacology 77 379 PMID: 24184417
Chou et al (2018) (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray. Neuropharmacology 139 1 PMID: 29953886
Akerboom et al (2012) Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci 32 13819 PMID: 23035093
Arenkiel et al (2012) Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing. PLoS One 6 e29423 PMID: 22216277
He et al (2012) Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology 37 1338 PMID: 22218089
Kolind et al (2012) Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity. Front Comput Neurosci 6 40 PMID: 22783184
Heinrich et al (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol 167 1003 PMID: 22394324
Upreti et al (2012) Altered neurotransmitter release, vesicle recycling and presynaptic structure in the PilC model of temporal lobe epilepsy. Brain 135 869 PMID: 22344585
Xu et al (2010) High precision and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. J Neurophysiol 103 2301 PMID: 20130040
Sun et al (2010) Canonical TGF-beta signaling is required for the balance of excitatory/inhibitory transmission within the hippocampus and prepulse inhibition of acoustic startle. J Neurosci 30 6025 PMID: 20427661
Dreyfus et al (2010) Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window. J Neurosci 30 99 PMID: 20053892
Goffin et al (2010) DA-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci 30 2935 PMID: 20181591
Welzel et al (2010) Synapse clusters are preferentially formed by synapses with large recycling pool sizes. PLoS One 5 e13514 PMID: 20976002
Dimitrov and Usdin (2010) Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons. J Comp Neurol 518 4375 PMID: 20853513
Kirwan et al (2015) Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro. Development 142 3178 PMID: 26395144
Telese et al (2015) LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation. Neuron 86 696 PMID: 25892301
Campbell et al (2015) Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Front Cell Neurosci 8 425 PMID: 25565960
Jaiswal et al (2015) Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Cell Death Dis 9 127 PMID: 25914623
Curcio et al (2015) Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Eneuro 6 e1645 PMID: 25675305
Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Neurosci 2 PMID: 26465004
Xu et al (2007) Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. Neuron 53 399 PMID: 17270736
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221 PMID: 17989288
Baldelli et al (2007) Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses. J Neurosci 27 13520 PMID: 18057210
Marinelli et al (2007) N-arachidonoyl-DA tunes synaptic transmission onto DArgic neurons by activating both cannabinoid and vanilloid receptors. Neuropsychopharmacology 32 298 PMID: 16760924
Smetana et al (2007) Muscarinic receptor activation elicits sustained, recurring depolarizations in reticulospinal neurons. J Neurophysiol 97 3181 PMID: 17344371
Sossa et al (2007) AMPAR exocytosis through NO modulation of PICK1. Neuropharmacology 53 92 PMID: 17555774
Limon et al (2007) Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus. Front Neural Circuits 104 15526 PMID: 17881566
Ting et al (2007) Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms. Proc Natl Acad Sci U S A 104 353 PMID: 17185415
Nakazawa et al (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. Biophys J 25 2867 PMID: 16710293
Qiu et al (2006) Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. J Neurosci 26 12943 PMID: 17167084
Rancillac et al (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. J Neurosci 26 6997 PMID: 16807329
Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci U S A 110 16622 PMID: 24046374
Medrihan et al (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nat Commun 4 1512 PMID: 23443540
Viemari et al (2013) β-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. EMBO J 7 179 PMID: 24273495
He et al (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition. J Neurophysiol 109 1535 PMID: 23255721
Tamburri et al (2013) NMDA-receptor activation but not ion flux is required for amyloid-β induced synaptic depression. PLoS One 8 e65350 PMID: 23750255
Taylor et al (2013) Axonal translation of β-catenin regulates synaptic vesicle dynamics. J Neurosci 33 5584 PMID: 23536073
Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurophysiol 33 11206 PMID: 23825423
Maejima et al (2013) Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice. Proc Natl Acad Sci U S A 33 5162 PMID: 23516282
Hira et al (2013) In vivo optogenetic tracing of functional corticocortical connections between motor forelimb areas. J Neurosci 7 55 PMID: 23554588
Stephenson-Jones et al (2013) Independent circuits in the basal ganglia for the evaluation and selection of actions. Proc Natl Acad Sci U S A 110 E3670 PMID: 24003130
Pi et al (2013) Cortical interneurons that specialize in disinhibitory control. Nature 503 521 PMID: 24097352
Yamagata et al (2013) Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices. Brain Res 1507 1 PMID: 23419897
Tyagarajan et al (2013) Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J Biol Chem 288 9634 PMID: 23408424
Zemoura et al (2013) Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors. J Biol Chem 288 34897 PMID: 24114844
Hur and Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553 PMID: 24381506
Neuser et al (2013) Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. PLoS One 8 e66497 PMID: 23840491
Yu et al (2013) Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice. PLoS One 8 e76049 PMID: 24069457
Berlinguer-Palmini et al (2013) GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses. PLoS One 8 e82180 PMID: 24312407
Nakatsuka et al (2003) Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. J Neurophysiol 89 3243 PMID: 12783958
Gao and Derbenev (2013) Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla. J Neurophysiol 110 2637 PMID: 24027107
Lado et al (2014) Electrophysiological characterization of male goldfish (Carassius auratus) ventral preoptic area neurons receiving olfactory inputs. Front Neurosci 8 185 PMID: 25071430
Wu et al (2013) Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses. J Neurosci 33 16158 PMID: 24107948
Rojas et al (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol 83 106 PMID: 23066089
Lee et al (2012) Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after PilC-induced status epilepticus. Neurochem Int 7 e38789 PMID: 22761705
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CNQX impact on field potentials PPR.
By
Anonymous on 06/07/2019
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Anterior singulate cortex
CNQX was used to study input of non-NMDA glutamate receptors into short-term plasticity in anterior cingulate cortex. Being applied in 5 microM concentration, CNQX reduced significantly both amplitudes of field potentials and their paired-pulse ratio.
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