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Submit Review2-Methylthioadenosine triphosphate tetrasodium salt
Description: Non-selective P2 agonist
Alternative Names: 2-Methylthio-ATP
Chemical Name: 2-Methylthioadenosine-5'-triphosphate tetrasodium salt
Purity: ≥98% (HPLC)
Biological Activity
2-Methylthioadenosine triphosphate tetrasodium salt is a P2 purinoceptor agonist.
Technical Data
| M. Wt | 641.2 |
| Formula | C11H14N5Na4O13P3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 100020-57-3 |
| PubChem ID | 16218831 |
| InChI Key | UEEFBRHXFDJPTA-KWIZKVQNSA-J |
| Smiles | NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC(SC)=N1.[Na+].[Na+].[Na+].[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Product Datasheets
References
References are publications that support the biological activity of the product.
Burnstock et al (1983) Studies on the stereoselectivity of the P2-purinoreceptor. Br.J.Pharmacol. 79 907 PMID: 6317121
Cusack et al (1982) Specific but non-competitive inhibition by 2-alkylthioanalogues of adenosine 5'-monophosphate and adenosine 5'-triphosphate of human platelet aggregation induced by adenosine 5'-diphosphate. Br.J.Pharmacol. 75 397 PMID: 7186826
Khakh et al (2001) International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol.Rev. 53 107 PMID: 11171941
McMurray et al (1998) Purinoceptor subtypes mediating contraction and relaxation of marmoset urinary bladder smooth muscle. Br.J.Pharmacol. 123 1579 PMID: 9605564
If you know of a relevant reference for 2-Methylthioadenosine triphosphate tetrasodium salt, please let us know.
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Keywords: 2-Methylthioadenosine triphosphate tetrasodium salt, 2-Methylthioadenosine triphosphate tetrasodium salt supplier, P2, purinergic, agonists, P2X, Receptors, Purinergic, P2Y, purinoceptors, 2-Methylthio-ATP, 1062, Tocris Bioscience
3 Citations for 2-Methylthioadenosine triphosphate tetrasodium salt
Citations are publications that use Tocris products. Selected citations for 2-Methylthioadenosine triphosphate tetrasodium salt include:
Nagai et al (2017) Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine 24 147 PMID: 28942281
Rahbar et al (2016) Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. Nature 11 e0154261 PMID: 27100625
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Med J Islam Repub Iran 509 119 PMID: 24784220
Do you know of a great paper that uses 2-Methylthioadenosine triphosphate tetrasodium salt from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.