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Submit ReviewBMS 453
Description: Synthetic retinoid and RARβ agonist; also RARα and RARγ antagonist
Alternative Names: BMS 189453
Chemical Name: 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for BMS 453
BMS 453 is a synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.
Technical Data for BMS 453
| M. Wt | 380.48 |
| Formula | C27H24O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 166977-43-1 |
| PubChem ID | 9875424 |
| InChI Key | VUODRPPTYLBGFM-CMDGGOBGSA-N |
| Smiles | CC(CC=C3C4=CC=CC=C4)(C)C(C3=C2)=CC=C2/C=C/C1=CC=C(C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BMS 453
References for BMS 453
References are publications that support the biological activity of the product.
Chen et al (1995) RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 14 1187 PMID: 7720709
Yang et al (2001) The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest. Oncogene 20 8025 PMID: 11753686
Monteiro et al (2009) Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. Stem Cells Dev. 18 457 PMID: 18690793
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Keywords: BMS 453, BMS 453 supplier, BMS453, retinoic, acid, receptors, RARβ, RARα, RARγ, RARalpha, RARbeta, RARgamma, RARa, RARb, RARg, agonists, antagonists, BMS189453, BMS, 189453, Retinoic, Acid, Receptors, 3409, Tocris Bioscience
3 Citations for BMS 453
Citations are publications that use Tocris products. Selected citations for BMS 453 include:
Mizee et al (2013) Retinoic acid induces blood-brain barrier development. J Neurosci 33 1660 PMID: 23345238
Wahl et al (2018) Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function. BMC Genomics 19 795 PMID: 30390632
Naylor et al (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun 7 12197 PMID: 27406002
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.