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Submit ReviewS 25585
Description: Potent and selective NPY Y5 receptor antagonist
Chemical Name: 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine
Purity: ≥98% (HPLC)
Biological Activity for S 25585
Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.
Technical Data for S 25585
| M. Wt | 528.5 |
| Formula | C22H23F3N4O6S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 263849-50-9 |
| PubChem ID | 10029880 |
| InChI Key | BRMJFKLHWFZWOQ-KOMQPUFPSA-N |
| Smiles | O=S(NC[C@H]1CC[C@H]([C@@](NNC(C3=CC=CC=C3)=O)=O)CC1)(C2=CC=C(C(F)(F)F)C=C2[N+]([O-])=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for S 25585
References for S 25585
References are publications that support the biological activity of the product.
Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489 PMID: 15601626
Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628
Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664
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Keywords: S 25585, S 25585 supplier, Potent, selective, NPY, Y5, antagonists, neuropeptide, Receptors, S25585, neuropeptides, 3432, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.