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Submit ReviewSID 7969543
Description: Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
Chemical Name: Ethyl 2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
Purity: ≥98% (HPLC)
Biological Activity for SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC50 values are 0.76, >33 and >33 μM at SF-1, RORα and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC50 = 30 nM).
Technical Data for SID 7969543
| M. Wt | 452.46 |
| Formula | C24H24N2O7 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 868224-64-0 |
| PubChem ID | 4076092 |
| InChI Key | KWMBIIQCLUIHDI-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC(OC(C)C(OCC)=O)=C1C=CN2CC(NC3=CC=C(OCCO4)C4=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SID 7969543
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.25 | 100 |
Preparing Stock Solutions for SID 7969543
The following data is based on the product molecular weight 452.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for SID 7969543
References for SID 7969543
References are publications that support the biological activity of the product.
Roth et al (2008) Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorg.med.Chem.Lett. 18 2628 PMID: 18374567
Madoux et al (2008) Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol.Pharmacol. 73 1776 PMID: 18334597
If you know of a relevant reference for SID 7969543, please let us know.
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Keywords: SID 7969543, SID 7969543 supplier, Selective, steroidogenic, factor-1, SF-1, NR5A1, inhibitors, inhibits, Nuclear, Receptors, Steroidogenic, Factor-1, SID7969543, Other, 3440, Tocris Bioscience
1 Citation for SID 7969543
Citations are publications that use Tocris products. Selected citations for SID 7969543 include:
Ting-Xin et al (2021) Global feather orientations changed by electric current. iScience 24 102671 PMID: 34179734
Do you know of a great paper that uses SID 7969543 from Tocris? Please let us know.
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