Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCyclosomatostatin
Description: Non-selective sst antagonist
Alternative Names: Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])
Purity: ≥95% (HPLC)
Biological Activity for Cyclosomatostatin
Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.
Technical Data for Cyclosomatostatin
| M. Wt | 779.98 |
| Formula | C44H57N7O6 |
| Sequence |
FWKT (Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-2 = D-Trp, Thr-4 = Bn-Thr), lactam bridge: Phe-1 to Thr-4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 84211-54-1 |
| PubChem ID | 122080 |
| InChI Key | YHVHQZYJGWGAKN-ZUWUZHNASA-N |
| Smiles | C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cyclosomatostatin
| Solubility | Soluble to 1 mg/ml in 20% ethanol / water |
Product Datasheets for Cyclosomatostatin
References for Cyclosomatostatin
References are publications that support the biological activity of the product.
Fries et al (1982) Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat. Peptides 3 811 PMID: 6129618
Stirnweis et al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503 PMID: 12182954
Guo et al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61 PMID: 18640104
If you know of a relevant reference for Cyclosomatostatin, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Cyclosomatostatin, Cyclosomatostatin supplier, Non-Selective, sst, receptor, antagonists, Receptors, Somatostatin, Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), 3493, Tocris Bioscience
5 Citations for Cyclosomatostatin
Citations are publications that use Tocris products. Selected citations for Cyclosomatostatin include:
Takashi et al (2022) Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway. Mol Psychiatry 27 1816-1828 PMID: 34737456
Chiara et al (2021) Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain. Theranostics 11 789-804 PMID: 33391505
Anaëlle et al (2020) Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1. Sci Adv 6 eaaz0517 PMID: 32494634
Tao et al (2020) APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development. PLoS One 15 e0239601 PMID: 33112876
Elliott et al (2015) Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263
Do you know of a great paper that uses Cyclosomatostatin from Tocris? Please let us know.
Reviews for Cyclosomatostatin
There are currently no reviews for this product. Be the first to review Cyclosomatostatin and earn rewards!
Have you used Cyclosomatostatin?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image