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Submit ReviewL-741,742 hydrochloride
Description: Highly selective D4 antagonist
Chemical Name: 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for L-741,742 hydrochloride
L-741,742 hydrochloride is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.
Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.
Technical Data for L-741,742 hydrochloride
| M. Wt | 417.38 |
| Formula | C23H25N2ClO.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 874882-93-6 |
| PubChem ID | 133008 |
| InChI Key | QDMAKDIDFJTXEL-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(ON=C1C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-741,742 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.17 | 10 |
Preparing Stock Solutions for L-741,742 hydrochloride
The following data is based on the product molecular weight 417.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.96 mL | 119.79 mL | 239.59 mL |
| 0.5 mM | 4.79 mL | 23.96 mL | 47.92 mL |
| 1 mM | 2.4 mL | 11.98 mL | 23.96 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
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Product Datasheets for L-741,742 hydrochloride
References for L-741,742 hydrochloride
References are publications that support the biological activity of the product.
Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D4 receptors. J. Med. Chem. 39 1943 PMID: 8642551
Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D4 receptor. J.Med.Chem. 40 2374 PMID: 9240352
If you know of a relevant reference for L-741,742 hydrochloride, please let us know.
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Keywords: L-741,742 hydrochloride, L-741,742 hydrochloride supplier, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, L741742, 1004, Tocris Bioscience
3 Citations for L-741,742 hydrochloride
Citations are publications that use Tocris products. Selected citations for L-741,742 hydrochloride include:
Root et al (2015) NE activates DA D4 receptors in the rat lateral habenula. J Neurosci 35 3460 PMID: 25716845
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 829 PMID: 27300435
Bastianetto et al (2006) Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci 7 28 PMID: 16573831
Do you know of a great paper that uses L-741,742 hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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