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Description: Hec1 inhibitor; causes arrest of mitosis
Chemical Name: N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for INH1
INH1 is a hec1 inhibitor. Binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10 - 20 μM).
Technical Data for INH1
| M. Wt | 344.86 |
| Formula | C18H16N2OS.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1780260-01-6 |
| PubChem ID | 71307591 |
| InChI Key | DYJVVODHGPIUPM-UHFFFAOYSA-N |
| Smiles | CC(C=C(C)C=C2)=C2C1=CSC(NC(C3=CC=CC=C3)=O)=N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for INH1
References for INH1
References are publications that support the biological activity of the product.
Wu et al (2008) Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 68 8393 PMID: 18922912
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Keywords: INH1, INH1 supplier, Hec1, inhibitors, inhibits, mitosis, arrests, Mitosis, 3551, Tocris Bioscience
1 Citation for INH1
Citations are publications that use Tocris products. Selected citations for INH1 include:
Linton et al (2014) An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma. Br J Cancer 110 510 PMID: 24327015
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.