Home / Pharmacology / GPCRs / 7-TM Receptors / Prostanoid Receptors / Prostanoid Receptor Antagonists / ONO AE3 208

ONO AE3 208

Cat. No. 3565 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: High affinity and selective EP4 antagonist
Chemical Name: 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ONO AE3 208

ONO AE3 208 is a high affinity and selective EP4 receptor antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively). Displays no affinity for EP1, EP2, DP or IP receptors (Ki >10 μM). Inhibits PGE2-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4+ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

Technical Data for ONO AE3 208

M. Wt 404.43
Formula C24H21FN2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 402473-54-5
PubChem ID 10111831
InChI Key MTDIMKNAJUQTIO-UHFFFAOYSA-N
Smiles O=C(C(C)C2=C(C=CC=C3)C3=C(F)C=C2)NC1=CC(C#N)=CC=C1CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ONO AE3 208

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.44 100

Preparing Stock Solutions for ONO AE3 208

The following data is based on the product molecular weight 404.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for ONO AE3 208

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for ONO AE3 208

References are publications that support the biological activity of the product.

Ma et al (2006) Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. Cancer Res. 66 2923 PMID: 16540639

Dey et al (2009) Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines. Br.J.Pharmacol 3 475 PMID: 19175605

Kabashima et al (2002) The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J.Clin.Invest. 109 883 PMID: 11927615

Deng et al (2013) Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells. J.Immunol. 190 3579 PMID: 23467936

If you know of a relevant reference for ONO AE3 208, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Prostanoid Receptor Antagonists

Keywords: ONO AE3 208, ONO AE3 208 supplier, ONOAE3208, selective, EP4, receptors, antagonists, prostanoids, PGE2, prostaglandins, high, affinity, orally, active, Prostanoid, Receptors, 3565, Tocris Bioscience

2 Citations for ONO AE3 208

Citations are publications that use Tocris products. Selected citations for ONO AE3 208 include:

Na-Ryum et al (2023) An airway-to-brain sensory pathway mediates influenza-induced sickness. Nature 615 660-667 PMID: 36890237

David M et al (2020) The transition of M-CSF-derived human macrophages to a growth-promoting phenotype. Blood Adv 4 5460-5472 PMID: 33166408

Do you know of a great paper that uses ONO AE3 208 from Tocris? Please let us know.

Reviews for ONO AE3 208

There are currently no reviews for this product. Be the first to review ONO AE3 208 and earn rewards!

Have you used ONO AE3 208?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review