Home / Pharmacology / Nuclear Receptors / Other Nuclear Receptors / Z-Guggulsterone

Z-Guggulsterone

Cat. No. 3570 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Broad spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat. No. 2013)
Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Z-Guggulsterone

Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).

Compound Libraries for Z-Guggulsterone

Z-Guggulsterone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Z-Guggulsterone

M. Wt 312.45
Formula C21H28O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 39025-23-5
PubChem ID 6450278
InChI Key WDXRGPWQVHZTQJ-OSJVMJFVSA-N
Smiles O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2CC[C@@]/4(C)[C@]([H])3CC(C4=C/C)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Z-Guggulsterone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.25 20 with gentle warming
ethanol 3.12 10 with gentle warming

Preparing Stock Solutions for Z-Guggulsterone

The following data is based on the product molecular weight 312.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 16 mL 80.01 mL 160.03 mL
1 mM 3.2 mL 16 mL 32.01 mL
2 mM 1.6 mL 8 mL 16 mL
10 mM 0.32 mL 1.6 mL 3.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Z-Guggulsterone

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Z-Guggulsterone

References are publications that support the biological activity of the product.

Singh et al (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate-dependent activation of c-Jun NH2-terminal kinase. Cancer Res. 67 7439 PMID: 17671214

Xiao and Singh (2008) z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol.Cancer Ther. 7 171 PMID: 18202020

Meyer et al (2005) Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study. J.Med.Chem. 48 6955 PMID: 16250653

If you know of a relevant reference for Z-Guggulsterone, please let us know.

View Related Products by Target

Keywords: Z-Guggulsterone, Z-Guggulsterone supplier, Broad, spectrum, steroid, receptor, ligands, Nuclear, Receptors, progesterone, mineralocorticoid, glucocorticoid, Other, 3570, Tocris Bioscience

2 Citations for Z-Guggulsterone

Citations are publications that use Tocris products. Selected citations for Z-Guggulsterone include:

Michael S et al (2021) Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host Microbe 29 988-1001.e6 PMID: 34010595

Ng et al (2016) C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties. Oncotarget 7 24005 PMID: 27006468

Do you know of a great paper that uses Z-Guggulsterone from Tocris? Please let us know.

Reviews for Z-Guggulsterone

There are currently no reviews for this product. Be the first to review Z-Guggulsterone and earn rewards!

Have you used Z-Guggulsterone?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review