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Submit ReviewZardaverine
Description: PDE3/4 inhibitor
Chemical Name: 6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
Purity: ≥98% (HPLC)
Biological Activity for Zardaverine
Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC50 values are 0.5 and 0.8 μM respectively).
Technical Data for Zardaverine
| M. Wt | 268.22 |
| Formula | C12H10F2N2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 101975-10-4 |
| PubChem ID | 5723 |
| InChI Key | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
| Smiles | COC1=C(OC(F)F)C=CC(=C1)C1=NNC(=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Zardaverine
References for Zardaverine
References are publications that support the biological activity of the product.
Galvan and Schudt (1990) Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle. Naunyn Schmiedebergs Arch.Pharmacol. 342 221 PMID: 1700309
Kilian et al (1989) Is phosphodiesterase inhibition a relevant bronchospasmolytic principle? Agents Actions Suppl. 28 331 PMID: 2683636
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Keywords: Zardaverine, Zardaverine supplier, PDE3/4, inhibitors, inhibits, Phosphodiesterases, 1046, Tocris Bioscience
4 Citations for Zardaverine
Citations are publications that use Tocris products. Selected citations for Zardaverine include:
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. J Neurosci 35 6639 PMID: 25926444
Gulyani et al (2009) Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp Neurol 215 236 PMID: 19013457
Zerani et al (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. Pain 183 279 PMID: 15531716
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