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Golgicide A

Cat. No. 3584 5 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, selective and reversible inhibitor of GBF1 ArfGEF
Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Golgicide A

Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data for Golgicide A

M. Wt 284.3
Formula C17H14F2N2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1139889-93-2
PubChem ID 25113626
InChI Key NJZHEQOUHLZCOX-FTLRAWMYSA-N
Smiles FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Golgicide A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.21 50

Preparing Stock Solutions for Golgicide A

The following data is based on the product molecular weight 284.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.03 mL 35.17 mL 70.35 mL
2.5 mM 1.41 mL 7.03 mL 14.07 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
25 mM 0.14 mL 0.7 mL 1.41 mL

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References for Golgicide A

References are publications that support the biological activity of the product.

Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157

If you know of a relevant reference for Golgicide A, please let us know.

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5 Citations for Golgicide A

Citations are publications that use Tocris products. Selected citations for Golgicide A include:

Guido et al (2021) Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade. Cell Death Differ 28 1733-1752 PMID: 33335289

Marta et al (2019) Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Glia 67 404-417 PMID: 30506943

Ryan T et al (2019) VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. Cell 178 748-761.e17 PMID: 31280962

Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034

Gomes-da-Silva et al (2019) Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ 26 1467 PMID: 30349077

Do you know of a great paper that uses Golgicide A from Tocris? Please let us know.

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