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Submit ReviewFluvoxamine maleate
Description: 5-HT reuptake inhibitor
Chemical Name: (E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate
Purity: ≥99%
Biological Activity for Fluvoxamine maleate
Fluvoxamine maleate is a selective serotonin reuptake inhibitor; antidepressant. Binds to the human 5-HT transporter with a Ki of 1.6 nmol/l.
Technical Data for Fluvoxamine maleate
| M. Wt | 434.41 |
| Formula | C15H21F3N2O2.C4H4O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% |
| CAS Number | 61718-82-9 |
| PubChem ID | 9560989 |
| InChI Key | LFMYNZPAVPMEGP-PIDGMYBPSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.COCCCC\C(C1=CC=C(C=C1)C(F)(F)F)=N/OCCN |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fluvoxamine maleate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 4.34 | 10 |
Preparing Stock Solutions for Fluvoxamine maleate
The following data is based on the product molecular weight 434.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.02 mL | 115.1 mL | 230.2 mL |
| 0.5 mM | 4.6 mL | 23.02 mL | 46.04 mL |
| 1 mM | 2.3 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
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Product Datasheets for Fluvoxamine maleate
References for Fluvoxamine maleate
References are publications that support the biological activity of the product.
Benfield and Ward (1986) Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs 32 313 PMID: 3096686
Classen et al (1977) Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br.J.Pharmacol. 60 505 PMID: 302726
Narita et al (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur.J.Pharmacol. 307 117 PMID: 8831113
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006
If you know of a relevant reference for Fluvoxamine maleate, please let us know.
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Keywords: Fluvoxamine maleate, Fluvoxamine maleate supplier, High, affinity, σ1, sigma1, ligands, 5-HT, reuptake, inhibitors, inhibits, Receptors, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, Sigma1, 1033, Tocris Bioscience
8 Citations for Fluvoxamine maleate
Citations are publications that use Tocris products. Selected citations for Fluvoxamine maleate include:
Su et al (2014) Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. PLoS One 7 435 PMID: 24396420
Fishback et al (2012) A 96-well filtration method for radioligand binding analysis of σ receptor ligands. J Pharm Biomed Anal 71 157 PMID: 22910107
O'Donnell et al (2010) The anti-inflammatory drug leflun. is an agonist of the aryl hydrocarbon receptor. PLoS One 5 PMID: 20957046
Nolan et al (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci 5 784 PMID: 25003748
Agarwal et al (2013) TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity. World J Gastroenterol 8 e63028 PMID: 23667566
Wood et al (2011) Serotonin, via HTR2 receptors, excites neurons in a cortical-like premotor nucleus necessary for song learning and production. J Neurosci 31 13808 PMID: 21957243
Hirano et al (2005) Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 144 695 PMID: 15678084
Kobayashi et al (2004) Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs. Neuropsychopharmacology 29 1841 PMID: 15150531
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.