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Estropipate

Cat. No. 3588 Submit a Review Datasheet / COA / SDS

Discontinued Product

3588 has been discontinued.

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Description: Estrogen receptor agonist and OATP1B1 inhibitor
Chemical Name: Piperazine estrone sulfate
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for Estropipate

Estrogen receptor agonist. Also inhibits organic anion transporting polypeptide 1B1 (OATP1B1) (IC50= 70 nM).

Technical Data for Estropipate

M. Wt 436.56
Formula C18H22O5S.C4H10N2
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 7280-37-7
PubChem ID 5284555
InChI Key HZEQBCVBILBTEP-ZFINNJDLSA-N
Smiles O=C4CC[C@@]3([H])[C@]2([H])CCC1=CC(OS(=O)(O)=O)=CC=C1[C@]([H])2CC[C@@]34C.C5NCCNC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Estropipate

References are publications that support the biological activity of the product.

Williams et al (2004) Estrogen regulation of the cytochrome P450 3A subfamily in humans. J.Pharmacol.Exp.Ther. 311 728 PMID: 15282264

Obaidat et al (2009) A cell-based high-throughput assay to identify inhibitors of organic anion transporting polypeptides 1B1 and 1B3. FASEB J. 23 748

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Keywords: Estropipate, Estropipate supplier, Estrogen, receptor, agonists, OATP1B, inhibitors, inhibits, and, Related, Receptors, Multidrug, Transporters, 3588, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Estropipate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Estropipate

Citations are publications that use Tocris products.

Currently there are no citations for Estropipate.

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Pathways for Estropipate

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.