Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVO-OHpic
Description: Potent PTEN inhibitor
Chemical Name: (OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen
Purity: ≥98% (HPLC)
Biological Activity for VO-OHpic
VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.
Technical Data for VO-OHpic
| M. Wt | 361.16 |
| Formula | C12H10N2O8V |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 675848-25-6 |
| PubChem ID | 90488861 |
| InChI Key | WUAQQAGTKWKWKQ-UHFFFAOYSA-K |
| Smiles | OC1=C2C([O-][V+2]3(O)([O-]C(C4=NC=CC=C4[O-]3)=O)([N]2=CC=C1)=O)=O.[H+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VO-OHpic
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.12 | 100 |
Preparing Stock Solutions for VO-OHpic
The following data is based on the product molecular weight 361.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.69 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for VO-OHpic
References for VO-OHpic
References are publications that support the biological activity of the product.
Rosivatz et al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780 PMID: 17240976
Sharma et al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845 PMID: 26601142
If you know of a relevant reference for VO-OHpic, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VO-OHpic, VO-OHpic supplier, 476310-60-08, potent, inhibitors, inhibits, PTEN, phosphate, tensin, homolog, deleted, chromosome, 10, Protein, Tyrosine, Phosphatases, 3591, Tocris Bioscience
1 Citation for VO-OHpic
Citations are publications that use Tocris products. Selected citations for VO-OHpic include:
Justyna et al (2022) Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules 12 PMID: 35454152
Do you know of a great paper that uses VO-OHpic from Tocris? Please let us know.
Reviews for VO-OHpic
There are currently no reviews for this product. Be the first to review VO-OHpic and earn rewards!
Have you used VO-OHpic?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image