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Submit ReviewVoglibose
Description: Orally active α-glucosidase inhibitor
Chemical Name: 3,4-Dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol
Biological Activity for Voglibose
Voglibose is an orally active α-glucosidase inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Exhibits antidiabetic and antiobesity activity in vivo.
Technical Data for Voglibose
| M. Wt | 267.28 |
| Formula | C10H21NO7 |
| Storage | Store at -20°C |
| CAS Number | 83480-29-9 |
| PubChem ID | 444020 |
| InChI Key | FZNCGRZWXLXZSZ-CIQUZCHMSA-N |
| Smiles | O[C@@H]1[C@](CO)(O)C[C@H](NC(CO)CO)[C@H](O)[C@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Voglibose
References for Voglibose
References are publications that support the biological activity of the product.
Matsuo et al (1992) Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am.J.Clin.Nutr. 55 314S PMID: 1728846
Matsui et al (2009) α-Glucosidase inhibition assay in an enzyme-immobilized amino-microplate. Anal.Sci. 25 559 PMID: 19359799
Moritoh et al (2009) Chronic administration of voglibose, an α-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J.Pharmacol.Exp.Ther. 329 669 PMID: 19208898
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Keywords: Voglibose, Voglibose supplier, Orally, active, α-glucosidase, alpha-glucosidase, inhibitors, inhibits, Glycosylases, 3596, Tocris Bioscience
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