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Submit ReviewRS 67333 hydrochloride
Description: 5-HT4 partial agonist
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for RS 67333 hydrochloride
RS 67333 hydrochloride is a potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo, with an intrinsic activity relative to 5-HT of 0.5.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data for RS 67333 hydrochloride
| M. Wt | 389.36 |
| Formula | C19H29ClN2O2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 168986-60-5 |
| PubChem ID | 9800491 |
| InChI Key | XVBGLZNYWUUAFF-UHFFFAOYSA-N |
| Smiles | Cl.CCCCN1CCC(CCC(=O)C2=CC(Cl)=C(N)C=C2OC)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RS 67333 hydrochloride
References for RS 67333 hydrochloride
References are publications that support the biological activity of the product.
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 receptor ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295
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Keywords: RS 67333 hydrochloride, RS 67333 hydrochloride supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67333, hydrochloride, 0989, Tocris Bioscience
5 Citations for RS 67333 hydrochloride
Citations are publications that use Tocris products. Selected citations for RS 67333 hydrochloride include:
Eriksson et al (2013) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Learn Mem 18 1096 PMID: 23032875
Warner-Schmidt et al (2009) Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci 29 1937 PMID: 19211900
Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453 PMID: 19649285
Huang and Kandel (2007) Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. J Neurosci 14 497 PMID: 17626908
Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. Obesity (Silver Spring) 27 3111 PMID: 17376972
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.