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Submit Review8-M-PDOT
Description: Melatonin agonist
Chemical Name: 8-Methoxy-2-propionamidotetralin
Purity: ≥99% (HPLC)
Biological Activity for 8-M-PDOT
8-M-PDOT is a melatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.
Technical Data for 8-M-PDOT
| M. Wt | 233.31 |
| Formula | C14H19NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 134865-70-6 |
| PubChem ID | 5170952 |
| InChI Key | RVIGBTUDFAGRTQ-UHFFFAOYSA-N |
| Smiles | CCC(=O)NC1CCC2=C(C1)C(OC)=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 8-M-PDOT
References for 8-M-PDOT
References are publications that support the biological activity of the product.
Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085
Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668
Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083
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Keywords: 8-M-PDOT, 8-M-PDOT supplier, Melatonin, agonists, Receptors, MT, 8MPDOT, (MT), 1035, Tocris Bioscience
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