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Submit ReviewVincristine sulfate
Description: Disrupts microtubules
Chemical Name: 22-Oxovincaleukoblastine
Purity: ≥95% (HPLC)
Biological Activity for Vincristine sulfate
Vincristine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.
Technical Data for Vincristine sulfate
| M. Wt | 923.04 |
| Formula | C46H56N4O10.H2SO4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2068-78-2 |
| PubChem ID | 249332 |
| InChI Key | AQTQHPDCURKLKT-JKDPCDLQSA-N |
| Smiles | OS(O)(=O)=O.[H][C@@]23N(C=O)C1=CC(OC)=[C@]([C@@]7([C@](OC)=O)C[C@H]6C[C@@](O)(CC)CN(CCC8=C7NC9=C8C=CC=C9)C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Vincristine sulfate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Vincristine sulfate
The following data is based on the product molecular weight 923.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.08 mL | 5.42 mL | 10.83 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 10 mM | 0.11 mL | 0.54 mL | 1.08 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
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Product Datasheets for Vincristine sulfate
References for Vincristine sulfate
References are publications that support the biological activity of the product.
Jordan et al (1985) Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45 2741 PMID: 3986806
Takano et al (1993) Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathol.Res.Pract. 189 197 PMID: 8321748
Wang et al (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis. Cancer Chemother.Pharmacol. 44 355 PMID: 10501907
If you know of a relevant reference for Vincristine sulfate, please let us know.
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Keywords: Vincristine sulfate, Vincristine sulfate supplier, Disrupts, microtubules, Tau, Tubulin, Mitosis, chemotherapeutics, Microtubules, 1257, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Vincristine sulfate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
9 Citations for Vincristine sulfate
Citations are publications that use Tocris products. Selected citations for Vincristine sulfate include:
Goldman et al (2015) Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun 6 6139 PMID: 25669750
Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840 PMID: 25493630
Zhang (2017) The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors. Mol Cancer Ther 16 1021 PMID: 28265007
Kathawala et al (2015) The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study. Oncotarget 6 510 PMID: 25402202
Torres et al (2016) Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells. Oncotarget 7 67373 PMID: 27634913
Kathawala et al (2014) Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study. Mol Cancer Ther 13 714 PMID: 24431074
Stojcheva et al (2016) MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM. Oncotarget 7 12937 PMID: 26887050
Mabe et al (2018) Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest 128 4413 PMID: 30148456
Heinemann et al (2011) Synergistic effects of oncolytic reovirus and doce. chemotherapy in prostate cancer. Sci Rep 11 221 PMID: 21645351
Do you know of a great paper that uses Vincristine sulfate from Tocris? Please let us know.
Reviews for Vincristine sulfate
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Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma.
By
Anonymous on 11/17/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Human epidermal carcinoma cell line
Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel,vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets