Ketoconazole

Cat. No. 1103 4 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Cytochrome P450c17 inhibitor

Chemical Name: cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine

Purity: ≥99% (HPLC)

Datasheet

Citations (4)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ketoconazole

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

Technical Data for Ketoconazole

M. Wt	531.44
Formula	C₂₆H₂₈Cl₂N₄O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	65277-42-1
PubChem ID	456201
InChI Key	XMAYWYJOQHXEEK-OZXSUGGESA-N
Smiles	ClC1=CC(Cl)=[C@]([C@]3(OC[C@@](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)([H])O3)CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ketoconazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	26.57	50
	DMSO	39.86	75

Preparing Stock Solutions for Ketoconazole

The following data is based on the product molecular weight 531.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	2.51 mL	12.54 mL	25.09 mL
3.75 mM	0.5 mL	2.51 mL	5.02 mL
7.5 mM	0.25 mL	1.25 mL	2.51 mL
37.5 mM	0.05 mL	0.25 mL	0.5 mL

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Product Datasheets for Ketoconazole

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Ketoconazole

References are publications that support the biological activity of the product.

Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515 PMID: 2724954

Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727 PMID: 9694927

Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371 PMID: 1472102

Merck Index 12 5313

Hubler et al (2018) Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 560 372 PMID: 30046109

Madhavan et al (2018) Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 15 700 PMID: 30046099

If you know of a relevant reference for Ketoconazole, please let us know.

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