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Submit ReviewCamptothecin
Description: DNA topoisomerase inhibitor
Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity: ≥98% (HPLC)
Biological Activity for Camptothecin
Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.
Technical Data for Camptothecin
| M. Wt | 348.36 |
| Formula | C20H16N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 7689-03-4 |
| PubChem ID | 24360 |
| InChI Key | VSJKWCGYPAHWDS-FQEVSTJZSA-N |
| Smiles | O=C4C5=C([C@](CC)(O)C(OC5)=O)C=C3C2=NC1=CC=CC=C1C=C2CN34 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Camptothecin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5 |
Preparing Stock Solutions for Camptothecin
The following data is based on the product molecular weight 348.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 57.41 mL | 287.06 mL | 574.12 mL |
| 0.25 mM | 11.48 mL | 57.41 mL | 114.82 mL |
| 0.5 mM | 5.74 mL | 28.71 mL | 57.41 mL |
| 2.5 mM | 1.15 mL | 5.74 mL | 11.48 mL |
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Product Datasheets for Camptothecin
References for Camptothecin
References are publications that support the biological activity of the product.
Liu (1989) DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 58 351 PMID: 2549853
Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 260 14873 PMID: 2997227
Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863 PMID: 8449612
Merck Index 12 1783
If you know of a relevant reference for Camptothecin, please let us know.
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Keywords: Camptothecin, Camptothecin supplier, DNA, topoisomerases, inhibitors, inhibits, Isomerases, chemotherapeutics, Topoisomerase, 1100, Tocris Bioscience
6 Citations for Camptothecin
Citations are publications that use Tocris products. Selected citations for Camptothecin include:
Hellinger et al (2013) Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol 151 299 PMID: 24216163
Gründemann et al (2013) Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One 8 e68016 PMID: 23840803
Lamy et al (2013) Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. PLoS One 8 e70846 PMID: 23936472
Herz et al (2017) Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide-Induced Cellular Inflammation Reaction. Evid Based Complement Alternat Med 2017 1950692 PMID: 28182113
Neveu et al (2016) CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia. Haematologica PMID: 27540136
Ma et al (2005) Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. Sci Rep 280 16208 PMID: 15687501
Do you know of a great paper that uses Camptothecin from Tocris? Please let us know.
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Literature in this Area
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Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.