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Submit ReviewNXY 059
Description: Free radical trapping agent; neuroprotectant
Chemical Name: 4-[[(1,1-Dimethylethyl)oxoimino]methyl]-1,3-benzenedisulfonic acid disodium salt
Purity: ≥98% (HPLC)
Biological Activity for NXY 059
NXY 059 is a free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.
Technical Data for NXY 059
| M. Wt | 381.33 |
| Formula | C11H13NNa2O7S2 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 168021-79-2 |
| PubChem ID | 6440181 |
| InChI Key | XLZOVRYBVCMCGL-BPNVQINPSA-L |
| Smiles | [Na+].[Na+].CC(C)(C)[N+](\[O-])=C\C1=C(C=C(C=C1)S([O-])(=O)=O)S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for NXY 059
References for NXY 059
References are publications that support the biological activity of the product.
Peeling et al (2001) Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology 40 433 PMID: 11166336
Sydserff et al (2002) Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br.J.Pharmacol. 135 103 PMID: 11786485
Culot et al (2009) Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res. 1294 144 PMID: 19631615
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