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Submit ReviewPregnanolone
Description: Postitive allosteric modulator of GABAA receptors
Chemical Name: (3α,5β)-3-Hydroxy-pregnan-20-one
Biological Activity for Pregnanolone
Pregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
Technical Data for Pregnanolone
| M. Wt | 318.49 |
| Formula | C21H34O2 |
| Storage | Store at RT |
| CAS Number | 128-20-1 |
| PubChem ID | 31402 |
| InChI Key | AURFZBICLPNKBZ-YZRLXODZSA-N |
| Smiles | C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pregnanolone
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 100 | |
| ethanol | 31.85 | 100 |
Preparing Stock Solutions for Pregnanolone
The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for Pregnanolone
References for Pregnanolone
References are publications that support the biological activity of the product.
Harrison et al (1987) Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 241 346 PMID: 3033209
Morris et al (1999) Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 56 752 PMID: 10496958
If you know of a relevant reference for Pregnanolone, please let us know.
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Keywords: Pregnanolone, Pregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, Receptors, 3652, Tocris Bioscience
Citations for Pregnanolone
Citations are publications that use Tocris products.
Currently there are no citations for Pregnanolone. Do you know of a great paper that uses Pregnanolone from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.