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Tenofovir

Cat. No. 3666 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
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Description: Reverse transcriptase inhibitor
Alternative Names: PMPA,(R)-9-(2-Phosphonoylmethoxypropyl)adenine
Chemical Name: (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Tenofovir

Tenofovir is a selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent.

Technical Data for Tenofovir

M. Wt 287.21
Formula C9H14N5O4P
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 147127-20-6
PubChem ID 464205
InChI Key SGOIRFVFHAKUTI-ZCFIWIBFSA-N
Smiles C[C@@H](OCP(O)(O)=O)CN(C=N2)C1=C2C(N)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tenofovir

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 28.72 100
DMSO 2.87 10

Preparing Stock Solutions for Tenofovir

The following data is based on the product molecular weight 287.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.41 mL 34.82 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for Tenofovir

References are publications that support the biological activity of the product.

Tsai et al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197 PMID: 7502044

Van Rompay et al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586 PMID: 8913470

Suo et al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250 PMID: 9765248

If you know of a relevant reference for Tenofovir, please let us know.

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Keywords: Tenofovir, Tenofovir supplier, Reverse, transcriptase, inhibitors, inhibits, Polymerases, RNA/DNA, Polymerase, antivirals, antiretrovirals, PMPA, (R)-9-(2-Phosphonoylmethoxypropyl)adenine, DNA, HIV, 3666, Tocris Bioscience

1 Citation for Tenofovir

Citations are publications that use Tocris products. Selected citations for Tenofovir include:

Joseph V et al (2023) ATP/ADP biosensor organoids for drug nephrotoxicity assessment. Front Cell Dev Biol 11 1138504 PMID: 36936695

Do you know of a great paper that uses Tenofovir from Tocris? Please let us know.

Reviews for Tenofovir

Average Rating: 5 (Based on 1 Review.)

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Study of in vivo tenofovir breakdown.
By Anonymous on 12/24/2019
Assay Type: In Vivo
Species: Mouse

We studied in vivo tenofovir breakdown.How it is converted to tenofovir.Tenofovir lacks a hydroxyl group in the position corresponding to the 3' carbon of the d-AMP and tenofovir was observed to cause premature termination of DNA transcription, preventing viral replication.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.