Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewCevimeline hydrochloride
Description: Selective M1 agonist
Alternative Names: AF 102B,SNI 2011
Chemical Name: cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride
Biological Activity for Cevimeline hydrochloride
Cevimeline hydrochloride is a selective M1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.
Technical Data for Cevimeline hydrochloride
| M. Wt | 235.77 |
| Formula | C10H17NOS.HCl |
| Storage | Store at -20°C |
| CAS Number | 107220-28-0 |
| PubChem ID | 76965955 |
| InChI Key | SKFLGMLYGHWKJG-RXUMEZLZSA-N |
| Smiles | C[C@@H](SC3)O[C@@]13CN2CCC1CC2.C[C@H](SC6)O[C@]46CN5CCC4CC5.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Cevimeline hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 17.68 | 75 | |
| DMSO | 11.79 | 50 |
Preparing Stock Solutions for Cevimeline hydrochloride
The following data is based on the product molecular weight 235.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 5.66 mL | 28.28 mL | 56.55 mL |
| 3.75 mM | 1.13 mL | 5.66 mL | 11.31 mL |
| 7.5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
| 37.5 mM | 0.11 mL | 0.57 mL | 1.13 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Cevimeline hydrochloride
References for Cevimeline hydrochloride
References are publications that support the biological activity of the product.
Wanibuchi et al (1990) Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 187 479 PMID: 1963596
Fisher et al (1991) (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 257 392 PMID: 2019998
Hargreaves et al (1992) L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors. Br.J.Pharmacol. 107 494 PMID: 1422595
If you know of a relevant reference for Cevimeline hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Cevimeline hydrochloride, Cevimeline hydrochloride supplier, AF102B, SNI2011, selective, M1, muscarinic, cholinergic, receptors, acetylcholine, Ach, agonists, AF, 102B, SNI, 2011, Receptors, 3689, Tocris Bioscience
1 Citation for Cevimeline hydrochloride
Citations are publications that use Tocris products. Selected citations for Cevimeline hydrochloride include:
Pasko et al (2020) Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 106 649-661.e4 PMID: 32197063
Do you know of a great paper that uses Cevimeline hydrochloride from Tocris? Please let us know.
Reviews for Cevimeline hydrochloride
There are currently no reviews for this product. Be the first to review Cevimeline hydrochloride and earn rewards!
Have you used Cevimeline hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.