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Submit ReviewMDL 72527
Description: Polyamine oxidase (PAO) inhibitor
Chemical Name: N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride
Biological Activity for MDL 72527
MDL 72527 is a polyamine oxidase (POA) inhibitor. Does not inhibit monoamine oxidase or D-Amino acid oxidase. Displays anticancer and neuroprotective activity in vivo.
Technical Data for MDL 72527
| M. Wt | 265.23 |
| Formula | C12H20N2.2HCl |
| Storage | Store at +4°C |
| CAS Number | 93565-01-6 |
| PubChem ID | 3035046 |
| InChI Key | ITVRWVVFVHINOH-UHFFFAOYSA-N |
| Smiles | C=C=CCNCCCCNCC=C=C.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MDL 72527
References for MDL 72527
References are publications that support the biological activity of the product.
Bey et al (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J.Med.Chem. 28 1 PMID: 3965702
Dogan et al (1999) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J.Neurochem. 72 765 PMID: 9930751
Basu et al (2009) A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 69 7689 PMID: 19773450
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Keywords: MDL 72527, MDL 72527 supplier, MDL72527, polyamine, oxidases, inhibitors, inhibits, POA, Other, Oxygenases/Oxidases, 3709, Tocris Bioscience
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