Home / Pharmacology / Transporters / Multidrug Transporters / Multidrug Transporter Inhibitors / Reversan

Reversan

Cat. No. 3722 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective MRP1 and P-gp inhibitor
Chemical Name: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Reversan

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Compound Libraries for Reversan

Reversan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Reversan

M. Wt 441.52
Formula C26H27N5O2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 313397-13-6
PubChem ID 2298706
InChI Key JTRXWCLQFAZHGP-UHFFFAOYSA-N
Smiles O=C(NCCCN5CCOCC5)C2=C1N=C(C4=CC=CC=C4)C=C(C3=CC=CC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Reversan

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.83 20

Preparing Stock Solutions for Reversan

The following data is based on the product molecular weight 441.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.32 mL 56.62 mL 113.25 mL
1 mM 2.26 mL 11.32 mL 22.65 mL
2 mM 1.13 mL 5.66 mL 11.32 mL
10 mM 0.23 mL 1.13 mL 2.26 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Reversan

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Reversan

References are publications that support the biological activity of the product.

Burkhart et al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573 PMID: 19654298

If you know of a relevant reference for Reversan, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Multidrug Transporter Inhibitors

Keywords: Reversan, Reversan supplier, MRP1, p-glycoprotein, p-gp, multidrug, resistance, associated, protein, 1, transporters, inhibitors, inhibits, selective, ABCB1, Multidrug, Transporters, 3722, Tocris Bioscience

1 Citation for Reversan

Citations are publications that use Tocris products. Selected citations for Reversan include:

James E et al (2020) Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. Int J Mol Sci 21 PMID: 33081264

Do you know of a great paper that uses Reversan from Tocris? Please let us know.

Reviews for Reversan

There are currently no reviews for this product. Be the first to review Reversan and earn rewards!

Have you used Reversan?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.