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Submit ReviewBYK 204165
Description: Selective PARP-1 inhibitor
Chemical Name: 4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
Purity: ≥99% (HPLC)
Biological Activity for BYK 204165
Potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively).
Technical Data for BYK 204165
| M. Wt | 252.27 |
| Formula | C15H12N2O2 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1104546-89-5 |
| PubChem ID | 25113764 |
| InChI Key | BTYSIDSTHDDAJW-LCYFTJDESA-N |
| Smiles | O=C(NC3=O)C1=CC=CC=C1/C3=C/C2=CC=CN2C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BYK 204165
References for BYK 204165
References are publications that support the biological activity of the product.
Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587 PMID: 18809672
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Keywords: BYK 204165, BYK 204165 supplier, BYK204165, PARP1, poly(ADP-ribose), polymerases, selective, inhibitors, inhibits, Poly(ADP-ribose), Polymerase, 3734, Tocris Bioscience
2 Citations for BYK 204165
Citations are publications that use Tocris products. Selected citations for BYK 204165 include:
Hallett et al (2016) Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma. Mol Oncol 10 1461 PMID: 27599694
Hamilton (2014) Cytotoxic effects of fascaplysin against small cell lung cancer cell lines. Lab Chip 12 1377 PMID: 24608973
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Cell Cycle and DNA Damage Research Product Guide
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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.