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Submit ReviewRN 1747
Description: Selective TRPV4 agonist
Chemical Name: 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Purity: ≥98% (HPLC)
Biological Activity for RN 1747
RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).
Compound Libraries for RN 1747
RN 1747 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for RN 1747
| M. Wt | 395.87 |
| Formula | C17H18ClN3O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1024448-59-6 |
| PubChem ID | 5068295 |
| InChI Key | ZNLVYSJQUMALEO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(S(N2CCN(CC3=CC=CC=C3)CC2)(=O)=O)C([N+]([O-])=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RN 1747
References for RN 1747
References are publications that support the biological activity of the product.
Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490 PMID: 19737537
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Keywords: RN 1747, RN 1747 supplier, RN1747, selective, TRPV4, agonists, transient, receptors, potential, channels, vanilloid, TRPV, 3745, Tocris Bioscience
4 Citations for RN 1747
Citations are publications that use Tocris products. Selected citations for RN 1747 include:
Christopher D et al (2020) Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes. Eur J Pharmacol 888 173441 PMID: 32810492
Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Am J Physiol Renal Physiol 21 4852 PMID: 25944998
Vizin et al (2015) TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats. Acta Physiol 214 275 PMID: 25739906
Shabir et al (2013) Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. World J Gastroenterol 305 F396 PMID: 23720349
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