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Submit ReviewGSK 264220A
Description: Endothelial lipase and lipoprotein lipase inhibitor
Chemical Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
Purity: ≥98% (HPLC)
Biological Activity for GSK 264220A
GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor (IC50 values are 0.13 and 0.10 μM respectively).
Technical Data for GSK 264220A
| M. Wt | 363.43 |
| Formula | C17H21N3O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 685506-42-7 |
| PubChem ID | 2810413 |
| InChI Key | LVOVQRPAMXCXTM-UHFFFAOYSA-N |
| Smiles | CC1=C(NC(NC2=CC=CC=C2)=O)C=C(S(N3CCCCC3)(=O)=O)O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GSK 264220A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.34 | 100 | |
| ethanol | 3.63 | 10 |
Preparing Stock Solutions for GSK 264220A
The following data is based on the product molecular weight 363.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.76 mL | 27.52 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.75 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets for GSK 264220A
References for GSK 264220A
References are publications that support the biological activity of the product.
Keller et al (2008) A high-throughput screen for the endothelial lipase using HDL as substrate. J.Biomol.Screen. 13 468 PMID: 18566479
Goodman et al (2009) Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg.Med.Chem.Letts. 19 27
If you know of a relevant reference for GSK 264220A, please let us know.
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Keywords: GSK 264220A, GSK 264220A supplier, GSK264220A, endothelial, lipase, lipoprotein, lipases, inhibitors, inhibits, Lipases, 3752, Tocris Bioscience
1 Citation for GSK 264220A
Citations are publications that use Tocris products. Selected citations for GSK 264220A include:
Pastor et al (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res 55 966 PMID: 24610889
Do you know of a great paper that uses GSK 264220A from Tocris? Please let us know.
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