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Voriconazole

Cat. No. 3760 1 Citation Submit a Review Datasheet / COA / SDS
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Description: Triazole antifungal agent
Alternative Names: UK 109496
Chemical Name: (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-((1H)-1,2,4-triazol-1-yl)-butan-2-ol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Voriconazole

Voriconazole is a triazole antifungal agent. Displays potent activity against Candida, Cryptococcus and Aspergillus species.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Voriconazole

M. Wt 349.31
Formula C16H14F3N5O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 137234-62-9
PubChem ID 71616
InChI Key BCEHBSKCWLPMDN-MGPLVRAMSA-N
Smiles O[C@]([C@@H](C)C2=NC=NC=C2F)(C3=C(F)C=C(F)C=C3)CN1C=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Voriconazole

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.93 100
ethanol 34.93 100

Preparing Stock Solutions for Voriconazole

The following data is based on the product molecular weight 349.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

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References for Voriconazole

References are publications that support the biological activity of the product.

Marco et al (1998) In vitro activities of voricon. (UK-190-496) and four other antifungal agents against 394 clinical isolates of Candida spp. Antimicrob.Agents Chemother. 42 161 PMID: 9449278

Kappe (1999) Antifungal activity of the new azole UK-109,496 (voriconazole). Mycoses 42 82

If you know of a relevant reference for Voriconazole, please let us know.

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Keywords: Voriconazole, Voriconazole supplier, UK109496, monotriazole, antifungal, agent, Miscellaneous, Pfizer, UK, 109496, Antifungals, 3760, Tocris Bioscience

1 Citation for Voriconazole

Citations are publications that use Tocris products. Selected citations for Voriconazole include:

Gyorgy et al (2022) Bile acid- and ethanol-mediated activation of Orai1 damages pancreatic ductal secretion in acute pancreatitis. J Physiol 600 1631-1650 PMID: 35081662

Do you know of a great paper that uses Voriconazole from Tocris? Please let us know.

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