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Submit ReviewMCOPPB trihydrochloride
Description: Potent NOP receptor agonist
Chemical Name: 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole trihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for MCOPPB trihydrochloride
MCOPPB trihydrochloride is a high affinity NOP receptor agonist (pKi = 10.07 for the human NOP receptor). Exhibits anxiolytic effects with no effect on memory or locomotion. Regarded as one of the most potent, non-peptide NOP full agonists in vitro.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for MCOPPB trihydrochloride
| M. Wt | 534.05 |
| Formula | C26H40N4.3HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1108147-88-1 |
| PubChem ID | 25208093 |
| InChI Key | DTIPEVOPCGEULQ-RFCADEKQSA-N |
| Smiles | CC5(CCCCCCC5)N(CC4)CCC4N2C1=CC=CC=C1N=[C@@]2[C@H]3CNCCC3.Cl.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for MCOPPB trihydrochloride
References for MCOPPB trihydrochloride
References are publications that support the biological activity of the product.
Hirao et al (2008) Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agent. J.Pharmacol.Sci. 106 361 PMID: 18319566
Hayashi et al (2009) Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain f J.Med.Chem. 52 610 PMID: 19125610
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.