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Submit ReviewAtorvastatin hemicalcium salt
Description: Potent HMG-CoA reductase inhibitor
Alternative Names: Lipitor
Chemical Name: (R,R)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
Purity: ≥99% (HPLC)
Biological Activity for Atorvastatin hemicalcium salt
Potent HMG-CoA reductase inhibitor (IC50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for Atorvastatin hemicalcium salt
| M. Wt | 577.67 |
| Formula | C33H34FN2O5.½Ca |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 134523-03-8 |
| PubChem ID | 60822 |
| InChI Key | FQCKMBLVYCEXJB-MNSAWQCASA-L |
| Smiles | [Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Atorvastatin hemicalcium salt
References for Atorvastatin hemicalcium salt
References are publications that support the biological activity of the product.
Istvan et al (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292 1160 PMID: 11349148
Vaughan et al (2004) Update on STAT: 2003. Circulation 110 886 PMID: 15313959
Santodomingo-Garzon et al (2006) AtoVas inhibits inflammatory hypernociception. Br.J.Pharmacol. 149 14 PMID: 16865092
Turner et al (2007) Comparison of the efficacies of five different STAT on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J.Cardiovasc.Pharmacol. 50 458 PMID: 18049315
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Keywords: Atorvastatin hemicalcium salt, Atorvastatin hemicalcium salt supplier, HMG-CoA, reductases, inhibitors, inhibits, cholesterol, biosynthesis, LDL, Pfizer, statins, Lipitor, Reductase, 3776, Tocris Bioscience
2 Citations for Atorvastatin hemicalcium salt
Citations are publications that use Tocris products. Selected citations for Atorvastatin hemicalcium salt include:
Nowak et al (2019) AtoVas and Conditioned Media from AtoVas-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo. Mediators Inflamm 2019 1868170 PMID: 31396016
Rojo-Arreola et al (2014) Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS One 9 e87594 PMID: 24489942
Reviews for Atorvastatin hemicalcium salt
Average Rating: 5 (Based on 1 Review.)
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Atorvastatin effect as Rho inhibitor.
By
Anonymous on 03/26/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: chondrocyte
used as alternative to simvastatin
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