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Sildenafil citrate

Cat. No. 3784 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent PDE5 inhibitor; orally active
Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Sildenafil citrate

Sildenafil citrate is an orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.

Compound Libraries for Sildenafil citrate

Sildenafil citrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Sildenafil citrate

M. Wt 666.7
Formula C22H30N6O4S.C6H8O7
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 171599-83-0
PubChem ID 135413523
InChI Key DEIYFTQMQPDXOT-UHFFFAOYSA-N
Smiles O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sildenafil citrate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.67 100

Preparing Stock Solutions for Sildenafil citrate

The following data is based on the product molecular weight 666.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.5 mL 7.5 mL 15 mL
5 mM 0.3 mL 1.5 mL 3 mL
10 mM 0.15 mL 0.75 mL 1.5 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

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Product Datasheets for Sildenafil citrate

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Sildenafil citrate

References are publications that support the biological activity of the product.

Ballard et al (1998) Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164 PMID: 9598563

Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds. Mol.Pharmacol. 56 124 PMID: 10385692

Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689 PMID: 16883306

Smith-Berdan et al (2019) Viagra enables efficient, single-day hematopoietic stem cell mobilization. Stem Cell Reports. PMID: 31607567

If you know of a relevant reference for Sildenafil citrate, please let us know.

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2 Citations for Sildenafil citrate

Citations are publications that use Tocris products. Selected citations for Sildenafil citrate include:

Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Development 8 e72155 PMID: 24015214

Xiaofeng et al (2021) Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage. Cell Chem Biol 28 1669-1678.e5 PMID: 34166610

Do you know of a great paper that uses Sildenafil citrate from Tocris? Please let us know.

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