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Submit ReviewMuristerone A
Description: Stimulates Bcl-XL mRNA transcription; antiapoptotic
Chemical Name: (2β,3β,5β,11α,22R)-2,3,5,11,14,20,22-Heptahydroxycholest-7-en-6-one
Purity: ≥97% (HPLC)
Biological Activity for Muristerone A
Muristerone A is an ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.
Technical Data for Muristerone A
| M. Wt | 496.63 |
| Formula | C27H44O8 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 38778-30-2 |
| PubChem ID | 122217 |
| InChI Key | LRJUYAVTHIEHAI-LHBNDURVSA-N |
| Smiles | O[C@@H]1[C@H](O)C[C@](C(C=C3[C@@]([H])2[C@H](O)C[C@@]4(C)[C@](O)3CC[C@@]([H])4[C@](O)(C)[C@H](O)CCC(C)C)=O)(O)[C@]2(C)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Muristerone A
References for Muristerone A
References are publications that support the biological activity of the product.
Patrick et al (2001) Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Tissue Eng. 7 303 PMID: 11429150
No et al (1996) Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc.Natl.Acad.Sci.USA 93 3346
Bosser and Zornig (2005) Agonists of an ecdysone-inducible mammalian expression system inhibit Fas-ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death Diff. 13 189
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Citations for Muristerone A
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Currently there are no citations for Muristerone A.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Muristerone A
