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Submit ReviewMM 11253
Description: RARγ-selective antagonist
Chemical Name: 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for MM 11253
MM 11253 is a selective RARγ antagonist. Blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.
Compound Libraries for MM 11253
MM 11253 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for MM 11253
| M. Wt | 462.67 |
| Formula | C28H30O2S2 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 345952-44-5 |
| PubChem ID | 10389639 |
| InChI Key | DPVGXUNWCVEIGT-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=C(C5(SCCS5)C3=CC(C=CC(C(O)=O)=C4)=C4C=C3)C=C2)C(C)(C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MM 11253
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.27 | 100 |
Preparing Stock Solutions for MM 11253
The following data is based on the product molecular weight 462.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.81 mL | 21.61 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets for MM 11253
References for MM 11253
References are publications that support the biological activity of the product.
Holmes et al (2000) Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J.Cell.Physiol. 185 61 PMID: 10942519
Le et al (2000) Modulation of retinoic acid receptor function alters the growth inhibitor response of oral SCC cells to retinoids. Oncogene 19 1457 PMID: 10723137
Dawson et al (2001) Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Res. 61 4723 PMID: 11406543
If you know of a relevant reference for MM 11253, please let us know.
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Keywords: MM 11253, MM 11253 supplier, MM11253, retinoids, retinoic, acid, receptors, antagonists, rarg, rargamma, rarγ, Retinoic, Acid, Receptors, 3822, Tocris Bioscience
7 Citations for MM 11253
Citations are publications that use Tocris products. Selected citations for MM 11253 include:
Perri et al (2014) BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells. Exp Cell Res 327 183 PMID: 25088254
Garnaas et al (2012) Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol 372 178 PMID: 22982668
Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687
Takashi et al (2023) Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase. Cancer Cell Int 23 94 PMID: 37198667
Bi et al (2018) All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. Cell Biosci 8 48 PMID: 30159139
Uchibe et al (2017) Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. J Orthop Res 35 1096 PMID: 27325507
Metzler et al (2018) RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development 145 PMID: 29986869
Do you know of a great paper that uses MM 11253 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.