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Rufinamide

Cat. No. 3828 Submit a Review Datasheet / COA / SDS
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Description: Prolongs inactivation of sodium channels; anticonvulsant
Alternative Names: CGP 33101
Chemical Name: 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Purity: ≥99% (HPLC)
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Biological Activity for Rufinamide

Rufinamide is a board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Technical Data for Rufinamide

M. Wt 238.19
Formula C10H8F2N4O
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 106308-44-5
PubChem ID 129228
InChI Key POGQSBRIGCQNEG-UHFFFAOYSA-N
Smiles O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rufinamide

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.82 100

Preparing Stock Solutions for Rufinamide

The following data is based on the product molecular weight 238.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.2 mL 20.99 mL 41.98 mL
5 mM 0.84 mL 4.2 mL 8.4 mL
10 mM 0.42 mL 2.1 mL 4.2 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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References for Rufinamide

References are publications that support the biological activity of the product.

Rogawski et al (2006) Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 69 273 PMID: 16621450

Arroyo (2007) Rufinamide. Neurotherapeutics 4 155 PMID: 17199032

White et al (2008) The anticonvulsant profile of rufin. (CGP 33101) in rodent seizure models. Epilepsia 49 1213 PMID: 18325020

If you know of a relevant reference for Rufinamide, please let us know.

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Citations for Rufinamide

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