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Submit ReviewUK 78282 hydrochloride
Description: Blocker of KV1.3 and KV1.4 channels
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for UK 78282 hydrochloride
UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.
Technical Data for UK 78282 hydrochloride
| M. Wt | 466.05 |
| Formula | C29H35NO2.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 136647-02-4 |
| PubChem ID | 53393337 |
| InChI Key | ZZSQARULZYQMIG-UHFFFAOYSA-N |
| Smiles | COC(C=C3)=CC=C3CCCN1CCC(COC(C4=CC=CC=C4)C2=CC=CC=C2)CC1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UK 78282 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.3 | 50 | |
| ethanol | 13.98 | 30 |
Preparing Stock Solutions for UK 78282 hydrochloride
The following data is based on the product molecular weight 466.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.29 mL | 21.46 mL | 42.91 mL |
| 2.5 mM | 0.86 mL | 4.29 mL | 8.58 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.29 mL |
| 25 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets for UK 78282 hydrochloride
References for UK 78282 hydrochloride
References are publications that support the biological activity of the product.
Hanson et al (1999) UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br.J.Pharmacol. 126 1707 PMID: 10372812
Chandy et al (2001) Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon 39 1269 PMID: 11384714
Chandy et al (2004) K+ channels as targets for specific immunomodulation. Trends.Pharmacol.Sci. 25 280 PMID: 15120495
If you know of a relevant reference for UK 78282 hydrochloride, please let us know.
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Citations for UK 78282 hydrochloride
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Reviews for UK 78282 hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Voltage gated Kv channel blocker with amazing research potential.
By
Anonymous on 10/15/2018
Assay Type: In Vitro
Species: Human
Voltage gated Kv channel blocking can be assessed under lab conditions with this product. UK 78782 is an excellent compound to get an understanding of channel blocking of different kind of Kv channel. Was dissolved in ethanol and easy to carry out HPLC on.
