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Description: Positive allosteric modulator of α7 nAChRs
Alternative Names: XY 4083
Chemical Name: [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide
Biological Activity for CCMI
CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.
Compound Libraries for CCMI
CCMI is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CCMI
| M. Wt | 388.25 |
| Formula | C19H15Cl2N3O2 |
| Storage | Store at -20°C |
| CAS Number | 917837-54-8 |
| PubChem ID | 67042344 |
| InChI Key | VMAKIACTLSBBIY-UHFFFAOYSA-N |
| Smiles | CC1=NOC(=C1)C(=CNC1=CC=C(Cl)C=C1)C(=O)NC1=CC=C(Cl)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CCMI
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.83 | 100 | |
| ethanol | 3.88 | 10 |
Preparing Stock Solutions for CCMI
The following data is based on the product molecular weight 388.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.88 mL | 25.76 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.15 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets for CCMI
References for CCMI
References are publications that support the biological activity of the product.
Gronlien et al (2007) Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 72 715 PMID: 17565004
Hu et al (2009) Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons. Br.J.Pharmacol. 158 1857 PMID: 20050184
Ng et al (2007) Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc.Natl.Acad.Sci.U.S.A. 104 8059 PMID: 17470817
If you know of a relevant reference for CCMI, please let us know.
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Keywords: CCMI, CCMI supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, Nicotinic, Receptors, Acetylcholine, XY4083, PAM, XY, 4083, (a7), 3837, Tocris Bioscience
Citations for CCMI
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Currently there are no citations for CCMI. Do you know of a great paper that uses CCMI from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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