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Submit ReviewSinomenine hydrochloride
Description: Anti-inflammatory; causes mast cell degranulation and histamine release
Chemical Name: 9α,13α,14α -7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Sinomenine hydrochloride
Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.
Technical Data for Sinomenine hydrochloride
| M. Wt | 365.85 |
| Formula | C19H23NO4.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 6080-33-7 |
| PubChem ID | 90488887 |
| InChI Key | YMEVIMJAUHZFMW-QKCNXVMZSA-N |
| Smiles | CN4C2[C@]3([H])[C@@](CC(C(OC)=C3)=O)(CC4)C1=C(O)C(OC)=CC=C1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Sinomenine hydrochloride
References for Sinomenine hydrochloride
References are publications that support the biological activity of the product.
Yamasaki (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 30 1 PMID: 61710
Desbordes et al (2008) High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602 PMID: 18522853
Wang et al (2008) Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 443 209 PMID: 18692550
Qian et al (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm. 4 23
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Keywords: Sinomenine hydrochloride, Sinomenine hydrochloride supplier, morphinan, analogs, anti-inflammatory, antinociceptive, histamine, mu-opioid, m-opioid, μ-opioid, opioids, agonists, stem, cells, Histaminergic-Related, Compounds, Mu, Opioid, Receptors, Stem, Cell, Proliferation, 3848, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.