Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewID 8
Description: Sustains self-renewal and pluripotency of ESCs
Chemical Name: 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Purity: ≥99% (HPLC)
Biological Activity for ID 8
ID 8 is a sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period). Also supports human PSC maintenance in combiantions with Wnt3a. DYRK inhibitor
Technical Data for ID 8
| M. Wt | 298.29 |
| Formula | C16H14N2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 147591-46-6 |
| PubChem ID | 791637 |
| InChI Key | VVZNWYXIOADGSW-UHFFFAOYSA-N |
| Smiles | CC2=C([N+]([O-])=O)C1=CC=C(O)C=C1N2C3=CC=C(OC)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ID 8
References for ID 8
References are publications that support the biological activity of the product.
Miyabayashi et al (2008) Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci.Biotechnol.Biochem. 72 1242 PMID: 18460821
Firestone and Chen (2009) Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem.Biol. 5 15
Hasegawa et al (2012) Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl.Med. 1 18 PMID: 23197636
View Related Products by Target
Keywords: ID 8, ID 8 supplier, Sustains, self-renewal, pluripotency, embryonic, stem, cells, ESCs, id8, id, 8, Stem, Cell, Proliferation, DYRK, 3853, Tocris Bioscience
Citations for ID 8
Citations are publications that use Tocris products.
Currently there are no citations for ID 8.
Reviews for ID 8
There are currently no reviews for this product. Be the first to review ID 8 and earn rewards!
Have you used ID 8?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.