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Submit Review1-Oleoyl lysophosphatidic acid sodium salt
Description: Endogenous agonist of LPA1 and LPA2
Chemical Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
Biological Activity
1-Oleoyl lysophosphatidic acid sodium salt is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. 1-Oleoyl lysophosphatidic acid sodium salt inhibits differentiation of neural stem cells (NSCs) into neurons.
Note: This product is typically prepared in PBS, pH 7.2, at a concentration of up to approximately 4 mg/mL.
Technical Data
| M. Wt | 458.5 |
| Formula | C21H40NaO7P |
| Storage | Store at -20°C |
| CAS Number | 325465-93-8 |
| PubChem ID | 44159357 |
| InChI Key | XGRLSUFHELJJAB-JGSYTFBMSA-M |
| Smiles | [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
van Corven et al (1992) Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Biochem.J. 281 163 PMID: 1731751
Dottori et al (2008) Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells. Stem Cells 26 1146 PMID: 18308941
Lapierre et al (2010) Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J.Biol.Chem. 285 25792 PMID: 20551326
If you know of a relevant reference for 1-Oleoyl lysophosphatidic acid sodium salt, please let us know.
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Keywords: 1-Oleoyl lysophosphatidic acid sodium salt, 1-Oleoyl lysophosphatidic acid sodium salt supplier, lysophosphatidic, acid, LPA, lysophospholipid, receptors, LPL-R, agonists, Lysophosphatidic, Acid, Receptors, Neural, Stem, Cells, 3854, Tocris Bioscience
10 Citations for 1-Oleoyl lysophosphatidic acid sodium salt
Citations are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:
Guang et al (2022) Human embryos in a dish - modeling early embryonic development with pluripotent stem cells. Cell Regen 11 4 PMID: 35029775
Maria et al (2022) Human blastoids model blastocyst development and implantation. Nature 601 600-605 PMID: 34856602
Natarajan V et al (2022) Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nat Cell Biol 24 858-871 PMID: 35697783
Jop et al (2022) A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression. Development 149 PMID: 35993866
Janet et al (2022) Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells. Cell Stem Cell 29 1346-1365.e10 PMID: 36055191
Maria et al (2023) Generating human blastoids modeling blastocyst-stage embryos and implantation. Nat Protoc 18 1584-1620 PMID: 36792779
Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. J Clin Invest 160 673 PMID: 25679761
Fernando Rodríguez et al (2021) Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis. Mol Neurobiol 58 470-482 PMID: 32974731
JoAnn et al (2021) α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis. J Cell Sci 134 PMID: 33722977
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Do you know of a great paper that uses 1-Oleoyl lysophosphatidic acid sodium salt from Tocris? Please let us know.
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Average Rating: 5 (Based on 3 Reviews.)
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LPA induces COX-2 expression in osteosacroma cells.
By
Anonymous on 12/13/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Osteosarcoma
MG-63 cells were pre-incubated with indicated inhibitors for 30 min followed by treatment with 10 µM LPA for 3 h to follow COX-2 expression using Western blot. All inhibitors prevented COX-2 induction by LPA.
Works to deplete stem cell pool.
By
Anonymous on 11/18/2018
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: mammary gland
Primary mouse mammary glands were digested, incubated with LPA or control at 5uM and then analyzed using CD24/CD29 to identify effects on the stem cell pool. A 50% reduction in the stem cell pool (p4) was identified after LPA treatment.
LPA induces COX-2 expression in MG-63 cells.
By
Christopher Trummer on 10/23/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Osteosarcoma
MG-63 cells were treated with 10 µM LPA (0-48 h) to follow COX-2 expression using Western blot. LPA induced COX-2 expression in a time-dependent manner in osteosarcoma cells.
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